静脉药物配置中心抗肿瘤药物不合理使用情况研究

Study on irrational use of antineoplastic drugs in pharmacy intravenous admixture service

目的 分析北京地区某医院静脉药物配置中心抗肿瘤药物的临床应用现状,了解某医院抗肿瘤药物的使用特点和规律,为临床合理用药提供参考.方法 采用回顾性研究的方法,提取某医院静脉配置中心2019年1月-2020年12月抗肿瘤药物医嘱共计23166条,分析抗肿瘤药物的不合理用药情况.结果 审核不合理抗肿瘤药物医嘱共894条,其中给药途径不适宜共327条(36.58%);溶媒剂量不适宜280条(31.32%);溶媒选择不适宜171条(19.13%);给药剂量不适宜73条(8.17%);品种选择不适宜36条(4.03%);配伍禁忌3条(0.34%);其他4条(0.45%).结论 某医院静脉药物配置中心的抗肿瘤药物医嘱存在一定的不合理现象,药师应加强不合理医嘱的审核及干预,加强抗肿瘤药物应用相关指南的学习,确保抗肿瘤药物安全合理使用.

0bjective To analyze the status quo of clinical application of antitumor drugs in intravenous drug dispensing center of a hospital in Beijing,and to understand the characteristics and rules of use of antitumor drugs in a hospital,so as to provide reference for clinical rational drug use.Method A total of 23,166 medical orders for antineoplastic drugs were extracted from the intravenous distribution center of a hospital from January 2019 to December 2020 by retrospective study,and the irrational use of antineoplastic drugs was analyzed.Resu Its A total of 894 unreasonable anti-tumor drug orders were reviewed,of which 327(36.58%)were unsuitable route of administration.The dose of solvent was not suitable for 280 cases(31.32%);171 cases(19.13%)were not suitable for solvent selection;73 cases(8.17%)showed unsuitable dosage.36 varieties were unsuitable(4.03%);3 incompatibilities(0.34%);the other four(0.45%).Cone I us i ons There are some unreasonable phenomenon in the medical orders of antineoplastic drugs in the intravenous drug dispensing center of a hospital.Pharmacists should strengthen the review and intervention of unreasonable medical orders and strengthen the study of relevant guidelines for the application of antineoplastic dnigs to ensure the safe and reasonable use of antineoplastic drugs.