吸入药物依从性测试中文版的信效度研究

Reliability and validity of the Chinese version of the test of the adherence to inhalers (TAI)

目的检验中文版吸入药物依从性测试(TAI)在我国慢性气道疾病人群中的信度及效度。方法对英文版TAI进行翻译、回译和文化调试,确定中文版量表条目。于2021年7—11月在中南大学湘雅二医院呼吸科门诊纳入165例慢阻肺和哮喘患者,使用中文版TAI、8项Morisky药物依从性量表(MMAS-8)进行施测。采用内容效度指数(CVI)及探索性因子分析分别检验中文版TAI的内容与结构效度,通过Pearson相关分析检验量表与效标的相关性。采用Cronbach′sα系数、分半信度和重测信度检验量表的信度。结果量表内容效度指数CVI为0.966。中文版TAI共10个条目,探索性因子分析提取出2个公因子,累计解释总变异量表的57.236%,各条目的因子载荷均>0.4,且条目归属与源量表一致。量表总分与MMAS-8的相关系数为0.835(P<0.001)。中文版TAI的Cronbach′sα系数为0.843,Guttman折半系数为0.796,重测信度为0.884(P<0.001)。结论中文版TAI在慢阻肺和哮喘人群中具有良好的信度和效度,可能为评估我国慢性气道疾病患者吸入药物依从性的可靠工具。

Objectives To evaluate the reliability and validity of the Chinese version of the test of the adherence to inhalers(TAI)in Chinese patients with chronic airway disease.Methods Based on the English version of TAI,the items of the Chinese version of TAI were determined after forward-backward translation and cultural adaption.Totally,165 patients with chronic obstructive pulmonary disease(COPD)and asthma were enrolled from Respiratory Clinic of the Second Xiangya Hospital of Central South University from July to November 2021,and a questionnaire survey was conducted using the Chinese version of TAI and the Morisky medication adherence scale 8-item version(MMAS-8).The content validity of the scale was expressed by content validity index(CVI)and the construct validity was analyzed by exploratory factor analysis(EFA).The convergence validity was evaluated by Pearson correlation analysis.The reliability of the scale was expressed by Cronbach′sαcoefficient,the split-half reliability and test-retest reliability.Results The CVI was 0.966.There were 10 items in total.Two factors were extracted from the Chinese version of TAI and the cumulative variance contribution rate was 57.236%.The load value of each item was more than 0.400 and the factor attribution of the item was consistent with the original scale.The total score of the Chinese version of TAI was positively correlated with the total score of the MMAS-8(r=0.835,P<0.001).The Cronbach′sαof the overall scale was 0.843,the Guttman′s half-reliability coefficient was 0.796 and the test-retest reliability was 0.884(P<0.001),respectively.Conclusions The Chinese version of TAI has good reliability and validity,which may be a reliable tool for evaluating the adherence to inhalers of patients with chronic airway disease in China.