阿尔茨海默病源性轻度认知障碍诊疗中国专家共识2021

Chinese expert consensus on the diagnosis and treatment of mild cognitive impairment due to Alzheimer′s disease 2021

随着社会人口老龄化的到来,阿尔茨海默病(AD)给全球公共卫生系统带来了沉重的社会和经济负担。AD在出现典型症状前20多年,脑组织就可能发生一系列的病理生理改变,在此过程中出现的轻度认知障碍(MCI),即AD源性MCI,是最早有临床症状的阶段,该阶段成为AD早期检测、诊断和防治最为重要的窗口。为满足临床实践需求,进一步提高广大医疗工作者对AD源性MCI的认知,中华医学会神经病学分会痴呆与认知障碍学组专家经多次研讨,制定了本《阿尔茨海默病源性轻度认知障碍诊疗中国专家共识》,以期为AD早期诊断、早期干预、精准治疗提供共识和指导方案。

As the aging society arriving,Alzheimer′s disease(AD)has brought heavy mental,psychological and socioeconomic burdens to the global public health.The pathophysiological changes of AD occur more than 20 years before the typical symptoms develop.During this process,mild cognitive impairment(MCI)appears as the earliest clinical manifestation,which would finally contribute to the clinical features of AD(MCI due to AD).Thus,MCI due to AD provides the most important opportunity for the early detection,diagnosis and prevention of AD.To provide guidance for physicians in clinical practice and promote further understanding of AD in this special stage,experts from the Chinese Society of Dementia and Cognitive Impairment have formulated this"Chinese expert consensus on the diagnosis and treatment of mild cognitive impairment due to Alzheimer′s disease",which includes epidemiology,etiology and mechanisms,diagnosis,treatment and prevention of MCI due to AD.