帕金森病冲动强迫行为的磁共振成像研究进展

Advances in magnetic resonance imaging of impulsive-compulsive behavior in Parkinson′s disease

在帕金森病的非运动症状中,冲动强迫行为(ICBs)的产生可能与多巴胺能功能障碍和替代治疗有关,目前对ICBs机制的理解和治疗的探索很大程度上依赖于神经影像学的研究。尽管研究结果之间存在矛盾,但多数研究证据表明帕金森病伴ICBs患者较帕金森病无ICBs患者在额叶、颞叶皮质厚度和皮质下核团的体积缩小,ICBs的发生与奖赏相关行为脑区的白质纤维束完整性相对保留有关。文中综述帕金森病相关ICBs的磁共振研究,包括皮质厚度、扩散张量成像、静息态及任务态功能磁共振分析,为后续进一步开展帕金森病相关ICBs的影像学研究、揭示发病机制和探索治疗方案提供新的探索方向。

Impulsive-compulsive behaviors(ICBs),one of the non-motor symptoms of Parkinson′s disease(PD),may be attributed to dopaminergic dysfunction and dopamine replacement therapy.At present,understanding of ICBs,mechanisms and exploration of treatment largely depend on neuroimaging research.Despite contradictions among the findings,most evidence indicated that PD patients with ICBs showed decreased thickness in frontal and temporal cortex and the volume of subcortical nuclei when compared to those without ICBs.And the occurrence of ICBs is associated with relatively preserved white-matter integrity in the brain regions involved in reward-related behaviors.This article will give an overview of the magnetic resonance research of PD related ICBs including cortical thickness,diffusion tensor imaging,resting state and task state functional magnetic resonance imaging analysis,which lays a foundation for further imaging studies,revealing the pathogenesis and exploring the potential treatment options.