摘要
白内障是全世界最常见的致盲性眼病,其发病机制尚不完全清楚。环状RNA(circRNA)是一种特殊的非编码RNA,具有较高的稳定性和保守性,广泛参与了多种生物学过程和疾病的发生。circRNA的异常表达可通过蛋白互作以及海绵吸附微小RNA影响晶状体上皮细胞的功能,从而参与白内障的发生,有望成为白内障防治的靶点。本文对circRNA在白内障发生及发展中作用的研究进展进行综述。
Cataract is the leading cause of visual impairment and blindness on a global scale.The pathogenesis of cataract is not completely understood.Circular RNAs(circRNAs)are a special kind of non-coding RNAs with high stability and conservation.They are widely involved in a variety of biological processes and diseases.Abnormal expression of circRNAs can participate in the development of cataract,affecting the function of lens epithelial cells through interacting with proteins and sponging microRNAs.They are possible targets for cataract prevention and treatment.This article reviews the research progress on the role of circRNAs in the occurrence and development of cataract.
作者
马诗雨
马竞
李丹
卢奕
Ma Shiyu;Ma Jing;Li Dan;Lu Yi(Department of Ophthalmology,Eye&ENT Hospital of Fudan University,NHC Key Laboratory of Myopia(Fudan University),Laboratory of Myopia,Chinese Academy of Medical Science,Shanghai 200031,China;Department of Facial Plastic and Reconstructive Surgery,Eye&ENT Hospital of Fudan University,Shanghai 200031,China)
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2022年第5期385-389,共5页
Chinese Journal of Ophthalmology
关键词
RNA
环状
白内障
晶体
上皮细胞
RNA,circular
Cataract
Lens,crystalline
Epithelial cells
