菸花苷对缺血性脑卒中大鼠的长期保护作用

Long-term protective effects of the nicotiflorin on ischemic stroke rats

目的探讨菸花苷对缺血性脑卒中大鼠的长期保护作用。方法建立大鼠脑缺血模型,观察菸花苷对于大鼠长期生存率、神经系统功能、体重及脑神经元的影响。结果菸花苷可以显著提高脑缺血大鼠的长期生存率,促进大鼠体重增加,减轻脑组织病理损伤,维持脑神经元形态及神经系统功能。结论菸花苷具有明显的对缺血性脑卒中大鼠的长期保护作用,其作用机制可能与保护脑神经元结构和功能有关。

Objective To investigate the long-term protective effects of the nicotiflorin on ischemic stroke rats.Methods Ischemic stroke model in rats was established for this study.The effects of nicotiflorin on long-term survival rate,nervous system function,body weight and brain neurons in rats were observed.Results The nicotiflorin had significantly improved the long-term survival rate of cerebral ischemia rats,which also promoted weight gain,alleviated pathological damage of brain tissue,maintained morphology of brain neurons and function of nervous system.Conclusion The nicotiflorin has obvious long-term protective effect on ischemic stroke rats and the mechanism may be related to the protection of the structure and function of brain neurons.