抗磷脂综合征孕母所娩新生儿急性呼吸窘迫1例分析

Analysis of a case of acute respiratory distress in newborns delivered by pregnant women with antiphospholipid syndrome

目的 探讨抗磷脂综合征孕妇所分娩新生儿呼吸窘迫的临床特点。方法 回顾1例抗磷脂综合征孕妇所生新生儿的临床资料并复习相关文献。结果 患儿,男,孕32+周分娩,因其母“妊娠合并抗磷脂综合征”剖宫产娩出,生后呼吸急促,予气管内反复注入肺泡表面活性物质及对症支持治疗后临床症状好转,逐渐脱氧、抗磷脂抗体转阴。结论 妊娠合并抗磷脂综合征者所分娩新生儿生后呼吸窘迫症状更加明显,可能与经胎盘传播被动获得的抗磷脂抗体有关,应引起临床重视。

Objective To explore the clinical characteristics of respiratory distress in newborns of pregnant women with antiphospholipid syndrome. Methods Clinical data of a newborn of pregnant women with antiphospholipid syndrome was retrospectively analyzed, and the related literature was reviewed. Results The child, male, 32+ weeks pregnant, was delivered by cesarean section due to his mother’s “pregnancy with antiphospholipid syndrome”. After birth, because of shortness of breath, repeated injection of alveolar surfactant, and other symptomatic and supportive treatments were treated. And then the child’s clinical symptoms was improved, gradually deoxygenated, and the antiphospholipid antibodies turned negative. Conclusion Respiratory distress symptoms of newborns born in pregnancy with antiphospholipid syndrome are more obvious after birth, which may be related to the passively acquired antiphospholipid antibodies transmitted through the placenta, and clinical attention should be paid.