流感病毒相关良性急性儿童肌炎的临床特点分析

Analysis of Clinical Features of Influenza Virus-associated Benign Acute Myositis in Children

目的:探讨流感病毒感染引起的良性急性儿童肌炎(BACM)的临床特点。方法:回顾性分析流感季收治的33例BACM患儿相关临床资料,对其发病特点、临床症状、实验室检查数据进行统计分析。结果:33例患儿中男26例,女7例,中位年龄7.6岁,甲型流感病毒阳性者4例(12.1%),乙型流感病毒阳性者24例(72.7%),二者均为阳性者5例(15.2%);流感病毒相关BACM多表现为上呼吸道感染症状2~4 d后出现双下肢肌痛;急性期小腿肌痛发生率为90%,2~7 d肌痛消失;实验室检查显示急性期肌酸激酶、谷草转氨酶均明显升高。结论:与甲型流感比较,乙型流感病毒相关BACM发病率更高;乙型流感病毒相关BACM多呈轻度及自限性病程。

Objective:To investigate the clinical characteristics of benign acute childhood myositis(BACM)caused by influenza virus infection.Methods:The relevant clinical data of BACM admitted to our hospital during the influenza season were retrospectively analyzed,and their disease characteristics,clinical symptoms and laboratory test data were statistically analyzed.Results:A total of 33 children were included in the study,26 boys and 7 girls,and the median age were 7.6 years.There were 4 cases(12.1%)of influenza A virus-positive,24 cases(72.7%)of influenza B virus-positive,and 5 cases(15.1%)of both positive patients.Influenza virus-associated BACM is mostly manifested as myalgia of both lower limbs after an upper respiratory tract infection of 2~4 days.The incidence of myalgia in the lower legs during the acute phase was 90%,and myalgia disappeared in 2~7 days.Laboratory tests showed that creatine kinase and aspartate aminotransferase were significantly elevated in the acute stage.Conclusion:Compared with influenza A,the incidence of BACM associated with the influenza B virus are more common.Influenza B virus-related BACM mostly has a mild and self-limiting course.