艾迪注射液联合5-氟尿嘧啶对乙型肝炎相关性肝癌患者免疫功能的影响

Effect of aidi injection combined with 5-fluorouracil on immune function in patients with hepatitis B-associated liver cancer

目的探讨艾迪注射液联合5-氟尿嘧啶对乙型肝炎相关性肝癌患者免疫功能的影响。方法将160例乙型肝炎相关性肝癌患者按治疗方式不同分为对照组(n=80)和观察组(n=80)。对照组患者采取5-氟尿嘧啶化疗,观察组患者在对照组患者的基础上采取艾迪注射液联合治疗。对比两组患者临床疗效、免疫功能指标(外周血CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平、血清肿瘤标志物[甲胎蛋白(AFP)、细胞间黏附分子-1(ICAM-1)、血管内皮生长因子(VEGF)]水平及不良反应发生情况。结果治疗后,观察组患者总有效率高于对照组,差异有统计学意义(P﹤0.05)。治疗后,两组患者外周血CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高,CD8^(+)水平均较治疗前下降,且观察组患者外周血CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者血清AFP、ICAM-1、VEGF水平均较治疗前降低,且观察组患者AFP、ICAM-1、VEGF水平均低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者恶心呕吐、发热、骨髓抑制、腹泻发生率均低于对照组,差异均有统计学意义(P﹤0.05)。结论艾迪注射液联合5-氟尿嘧啶能够调节乙型肝炎相关性肝癌患者免疫功能,降低血清AFP、ICAM-1、VEGF水平,减少化疗药物的不良反应,提高治疗效果。

Objective To investigate the effect of addie injection combined with 5-fluorouracil on immune function of patients with hepatitis B-associated liver cancer.Method A total of 160 patients with hepatitis B-associated liver cancer were divided into control group(n=80)and observation group(n=80)according to different treatment methods.The patients in the control group were given 5-fluorouracil chemotherapy,and the patients in the observation group were given the combined treatment of aidi injection based on the patients in the control group.The clinical efficacy,immune function indexes(peripheral blood CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))levels,serum tumor markers[α-fetal protein(AFP),cell adhesion molecules-1(ICAM-1),vascular endothelial growth factor(VEGF)]levels and the occurrence of adverse events were compared between the two groups.Result After the treatment,the effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in peripheral blood of the two groups of patients were increased than before the treatment,and the levels of CD8^(+)were decreased than before the treatment,and the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in peripheral blood of patients in the observation group were higher than those in the control group,and the level of CD8^(+)was lower than that of the control group,the differences were statistically significant(P<0.05).After the treatment,the levels of serum AFP,ICAM-1,and VEGF in the two groups were lower than before the treatment,and the levels of AFP,ICAM-1,and VEGF in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidences of nausea and vomiting,fever,bone marrow suppression,and diarrhea in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Aidi injection combined with 5-fluorouracil could regulate the immune function of patients with hepatitis B-associated liver cancer,reduce the levels of serum AFP,ICAM-1,and VEGF,reduce the risk of adverse events owing to chemotherapy drugs,and improve their clinical effect.