血管内皮生长因子、糖类抗原125、糖类抗原19-9在宫颈癌中的表达及临床价值

Expression of vascular endothelial growth factor,carbohydrate antigen 125,and carbohydrate antigen 19-9 in cervical cancer and their clinical value

目的探究血管内皮生长因子(VEGF)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)在宫颈癌中的表达及临床价值。方法收集宫颈病变患者200例,经组织病理学检查确诊宫颈癌82例,良性病变118例。分析不同疾病患者的VEGF、CA125、CA19-9表达水平;比较不同肿瘤直径、分化程度宫颈癌患者VEGF、CA125、CA19-9阳性表达率;分析宫颈癌患者VEGF、CA125、CA19-9水平与临床分期的相关性;分析VEGF、CA125、CA19-9单独及联合检测对宫颈癌的诊断价值。结果宫颈癌患者VEGF、CA125、CA19-9表达水平均明显高于良性病变患者,差异均有统计学意义(P﹤0.01)。肿瘤直径﹥4 cm宫颈癌患者VEGF、CA125、CA19-9阳性表达率均明显高于肿瘤直径≤4 cm患者,差异均有统计学意义(P﹤0.01)。低分化宫颈癌患者VEGF、CA125、CA19-9阳性表达率均高于中高分化患者,差异均有统计学意义(P﹤0.05)。Spearman相关性分析结果显示,宫颈癌患者的VEGF、CA125、CA19-9水平与临床分期均呈正相关(P﹤0.01)。VEGF、CA125、CA19-9联合检测诊断宫颈癌的曲线下面积(AUC)和截断值均高于VEGF、CA125、CA19-9单独检测。结论VEGF、CA125、CA19-9在宫颈癌中的表达水平显著高于良性病变患者,三者表达情况与肿瘤直径、分化程度、临床分期密切相关,对疾病进展有重要提示作用,且可用于宫颈癌诊断,综合临床价值很高。

Objective To investigate the expression of vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),and carbohydrate antigen 19-9(CA19-9)in cervical cancer and their clinical value.Method A total of200 patients with cervical lesions were collected,82 were diagnosed with cervical cancer,and 118 were benign lesions by the histopathological examination.The expression levels of VEGF,CA125,and CA19-9 in patients with different diseases were analyzed.The positive rates of VEGF,CA125,and CA19-9 in cervical cancer patients with different tumor diameters and differentiation grades were compared.The correlation between VEGF,CA125,CA19-9 levels and clinical stage in patients with cervical cancer was analyzed.The diagnostic value of VEGF,CA125,CA19-9 alone and combined detection in cervical cancer was analyzed.Result The expression levels of VEGF,CA125,and CA19-9 in patients with cervical cancer were significantly higher than those in patients with benign lesions,and the differences were statistically significant(P<0.01).The positive rates of VEGF,CA125,and CA19-9 in cervical cancer patients with tumor diameter>4 cm were significantly higher than those in patients with tumor diameter≤4 cm(P<0.01).The positive rates of VEGF,CA125,and CA19-9 in patients with poorly differentiated cervical cancer were higher than those in patients with moderate-to-high differentiation,and the differences were statistically significant(P<0.05).The results of Spearman correlation analysis showed that the levels of VEGF,CA125,and CA19-9 in cervical cancer patients were positively correlated with the clinical stage(P<0.01).The combined detection of VEGF,CA125,and CA19-9 had more area under the curve(AUC)and higher cut-off value in the diagnosis of cervical cancer than the indicators alone.Conclusion The levels of VEGF,CA125,and CA19-9 in cervical cancer are significantly higher than those in benign lesions.The expression of these indicators is closely related to the tumor diameter,differentiation grade,and clinical stage,which have important hints for disease progression and could be used for cervical cancer diagnosis.The detection of these indicators has a high comprehensive clinical value.