摘要
葫芦脲(CB[n])的直接衍生化一直是一项难题。本文用臭氧氧化法将CB[6]衍生化,合成全羟基葫芦[6]脲((OH)_(12)CB[6])。CB[6]与O_(3)在20℃下反应22h,生成(OH)_(12)CB[6]的产率为44%,并探究了丙酮扩散法、柱层析法和DMSO提纯法三种去除无机盐的方法的可行性。臭氧由电解水制得,成本低,没有二次污染,且臭氧氧化能力强,在室温下即可氧化葫芦脲。本文为合成全羟基葫芦脲提供了新的方法。
Direct functionalization of cucurbituril(CB[n]) has been a long standing dilemma due to its rigid structure,poor solubility and the limitation of only C-H bonds for activation.In this work,the perhydroxycucurbit[6]uril((OH)_(12)CB[6]) was successfully prepared by oxidizing CB[6] with O_(3).Reaction of CB[6] with O_(3) in sulfuric acid at 20℃ for 22 h produced(OH)_(12)CB[6] with a yield of 44%.Three methods of purifying(OH)_(12)CB[6] were investigated,including acetone diffusion,column chromatography and DMSO purification,and the best purifying way was to use the anhydrous DMSO.In this work,O_(3) was obtained simply and environmentally friendly by electrolysis of water,which is highly oxidizing and can oxidize CB[6] at room temperature.This work provides a new method for the synthesis of hydroxycucurbituril.
作者
程芷琰
张海波
周晓海
Cheng Zhiyan;Zhang Haibo;Zhou Xiaohai(School of Health,Dongguan Polytechnic,Dongguan,523186;College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,430072)
出处
《化学通报》
CAS
CSCD
北大核心
2022年第5期630-633,共4页
Chemistry
关键词
臭氧氧化
葫芦脲
羟基葫芦脲
Cucurbituril
Ozone oxidation
Hydroxycucurbituril
