癫痫无发作患者停药后复发的影响因素

Influencing factors of recurrence in patients without seizures after drug withdrawal

目的:探讨癫痫无发作患者停药后复发的影响因素。方法:回顾性分析2018年1月至2020年1月80例癫痫无发作患者的临床资料,依据患者停药后是否复发分为复发组(n=35)与未复发组(n=45)。比较两组临床资料,采用Logistic回归分析探讨癫痫无发作患者停药后复发的影响因素。结果:复发组用药前发作次数>5次占比、颅内病灶占比、药物治疗3个月时未完全控制占比、抗癫痫药物种类≥2种占比均高于未复发组,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,用药前发作次数>5次、有颅内病灶、药物治疗3个月时未完全控制、抗癫痫药物种类≥2种均为癫痫无发作患者停药后复发的独立危险因素(OR>1,P<0.05)。结论:用药前发作次数>5次、有颅内病灶、药物治疗3个月时未完全控制、抗癫痫药物种类≥2种均为癫痫无发作患者停药后复发的独立危险因素。

Objective: To explore influencing factors of recurrence in patients without seizures after drug withdrawal. Methods: The clinical data of 80 patients without seizures from January 2018 to January 2020 were retrospectively selected, and they were divided into recurrence group(n=35) and non-recurrence group(n=45) according to whether the recurrence occurred or not after drug withdrawal. The clinical data of the two groups were compared. Logistic regression analysis was used to explore the influencing factors of recurrence after drug withdrawal in the patients without seizures. Results: The proportion of seizures >5 times before medication, the proportion of intracranial lesions, the proportion of incomplete control after 3 months of drug treatment, and the proportion of ≥2 types of antiepileptic drugs in the recurrence group were higher than those in the non-recurrence group, and the differences were statistically significant Significance(P<0.05). The multivariate Logistic regression analysis showed that the number of seizures before medication >5, intracranial lesions, incomplete control after 3 months of drug treatment, and ≥2 types of antiepileptic drugs were the independent risk factors for the recurrence after drug withdrawal in the patients without seizures(OR>1, P<0.05). Conclusions: The number of seizures before medication >5, intracranial lesions, incomplete control after 3 months of drug treatment, and ≥2 types of antiepileptic drugs are the independent risk factors for the recurrence after drug withdrawal in the patients without seizures.