脑梗死急性期患者血清PAI⁃1、ICAM⁃1和GMP⁃140的水平变化及临床意义

Changes and clinical significance of serum PAI⁃1,ICAM⁃1 and GMP⁃140 levels in patients with acute cerebral infarction

目的分析脑梗死急性期患者血清纤溶酶原激活剂抑制物⁃1(PAI⁃1)、细胞间黏附分子⁃1(ICAM⁃1)、血小板α颗粒膜蛋白⁃140(GMP⁃140)的水平变化及临床意义。方法选取2017年5月至2020年4月开滦总医院林西医院收治的98例脑梗死患者作为研究组,选取同时间段57例健康体检者作为对照组。比较两组以及急性期、恢复期脑梗死患者的PAI⁃1、ICAM⁃1、GMP⁃140水平,分析影响脑梗死急性期患者预后的单因素、多因素。结果研究组PAI⁃1、ICAM⁃1、GMP⁃140水平均高于对照组,差异有统计学意义(P<0.05)。急性期患者PAI⁃1、ICAM⁃1、GMP⁃140水平均高于恢复期,差异有统计学意义(P<0.05)。年龄、性别、吸烟等非影响脑梗死急性期患者预后的单因素(P>0.05),高血压、PAI⁃1、ICAM⁃1、GMP⁃140为影响脑梗死急性期患者预后的单因素(P<0.05)。经多因素Logistic回归模型分析结果得出,高血压、PAI⁃1、ICAM⁃1、GMP⁃140为脑梗死急性期患者预后的独立危险因素(P<0.05)。结果PAI⁃1、ICAM⁃1、GMP⁃140与脑梗死急性期的发生发展有着密切联系,可作为判断脑梗死急性期患者病情变化及预后的标志。

Objective To analyze the changes of serum plasminogen activator inhibitor⁃1(PAI⁃1),intercellular adhesion molecule⁃1(ICAM⁃1),plateletα⁃granule membrane protein⁃140(GMP⁃140)levels in patients with cerebral infarction and clinical significance.Methods The clinical data of 98 patients with cerebral infarction admitted in Linxi Hospital of Kailuan General Hospital from May to April 2017 to April 2020 were selected as the research group,and another 57 cases who had health examination during the same period were selected as the control group.The levels of PAI⁃1,ICAM⁃1 and GMP⁃140 in the two groups and in patients with acute and convalescent cerebral infarction were compared,and the single factor and multiple factors affecting the prognosis of patients with acute cerebral infarction were analyzed.Results The levels of PAI⁃1,ICAM⁃1,and GMP⁃140 in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of PAI⁃1,ICAM⁃1 and GMP⁃140 in patients in the acute stage were higher than those in the recovery stage,and the difference was statistically significant(P<0.05).Age,gender,smoking and other factors did not affect the prognosis of patients with acute cerebral infarction(P>0.05).Hypertension,PAI⁃1,ICAM⁃1 and GMP⁃140 were the single factors affecting the prognosis of patients with acute cerebral infarction(P<0.05).The results of multi⁃factor Logistic regression model showed that high blood pressure,PAI⁃1,ICAM⁃1,GMP⁃140 were independent risk factors for the prognosis of patients with cerebral infarction(P<0.05).Conclusion PAI⁃1,ICAM⁃1,GMP⁃140 are closely related to the occurrence and development of cerebral infarction in the acute phase,and can be used as markers for judging the changes and prognosis of patients with cerebral infarction in the acute phase.