喉癌组织中Sox2、cMyc表达与其临床病理特征及预后的相关性

Correlation of Sox2 and cMyc expression in laryngeal carcinoma with clinicopathological features and prognosis

目的探究喉癌组织中Sox2、cMyc表达与其临床病理特征及预后的相关性。方法选取2017年1月至2021年1月重庆医科大学附属永川医院收治的98例喉癌组织(作为喉癌组)及相应癌旁正常组织(作为癌旁组)。比较两组中Sox2、cMyc阳性表达率,分析喉癌组织中Sox2、cMyc表达与病理特征、预后的关系。结果喉癌组的Sox2、cMyc阳性表达率均高于癌旁组,差异有统计学意义(P<0.05)。喉癌组织的Sox2、cMyc阳性表达与T分期、淋巴结转移有关(P<0.05);与年龄、性别、吸烟史、饮酒史、临床分期、临床分型、分化程度无明显相关性(P>0.05)。本研究喉癌患者的1年总生存率为85.71%(84/98)。Sox2阳性表达组(80.82%)1年生存率低于阴性表达组(100.00%),cMyc阳性表达组(80.28%)1年生存率低于阴性表达组(100.00%),差异均有统计学意义(P<0.05)。单因素分析结果显示,淋巴结转移、临床分期、T分期、Sox2及cMyc是影响喉癌预后的危险因素(P<0.05)。Cox回归分析显示,T分期、淋巴结转移、Sox2阳性、cMyc阳性为喉癌预后不良的独立影响因素(P<0.05)。结论喉癌组织中Sox2、cMyc阳性表达与T分期、淋巴结转移及预后密切相关,可作为喉癌预后不良的独立评估指标。

Objective To investigate the correlation between the expression of Sox2 and cMyc in laryngeal carcinoma and its clinicopathological features and prognosis.Methods The expression of Sox2 and cMyc in 98 cases of laryngeal carcinoma and adjacent normal tissues treated in Yongchuan Hospital Affiliated to Chongqing Medical University from January 2017 to January 2021 was detected by immunohistochemical method,and the relationship between the expression of Sox2 and cMyc and pathological features and prognosis of laryngeal carcinoma was analyzed.Results The positive expression rates of Sox2 and cMyc in the laryngeal cancer group were higher than those in the para⁃cancer group,and the differences were statistically significant(P<0.05).The positive expressions of Sox2 and cMyc in laryngeal carcinoma tissues were correlated with T stage and lymph node metastasis,and the differences were statistically significant(P<0.05).There was no significant correlation with age,sex,and smoking history,drinking history,clinical stage,clinical typing and differentiation degree(P>0.05).The 1⁃year survival rate of laryngeal cancer patients in this study was 85.71%(84/98).The 1⁃year survival rate in the Sox2 positive expression group(80.82%)was lower than that in the negative expression group(100.00%),and the 1⁃year survival rate in the cMyc positive expression group(80.28%)was lower than that in the negative expression group(100.00%),with statistical significance(P<0.05).Univariate analysis showed that lymph node metastasis,clinical stage,T stage,Sox2 and cMyc were the risk factors affecting the prognosis of laryngeal cancer(P<0.05).Cox regression analysis showed that T stage,lymph node metastasis,positive Sox2 and positive cMyc were independent influencing factors for poor prognosis of laryngeal cancer(P<0.05).Conclusion The positive expressions of Sox2 and cMyc in laryngeal cancer tissues are closely related to T stage,lymph node metastasis and prognosis,and can be used as independent evaluation indicators for poor prognosis of laryngeal cancer.