帕金森病患者面部表情减退研究进展

Novel Developments in Hypomimia in Parkinson’s Disease

帕金森病显著的临床特征之一是面部表情减退,主要表现为自主性、情绪性等面部表情受损,且通常是双侧对称的。近年来有大量研究阐述了帕金森病表情减退发生的相关机制,包括含基底核区功能障碍、面部情绪识别功能缺陷、认知功能障碍等因素,但具体的病理、生理机制尚未明确。表情减退与帕金森病进程密切相关,因此,对表情减退进行科学地量化与评估对于帕金森病的诊治具有重要意义。此外,关于其治疗方案也仍然存在争议。本文就帕金森病患者表情减退的临床表现、发生机制、治疗研究进展做一综述。

Hypomimia is one prominent clinical symptom of Parkinson’s disease(PD),which is mainly characterized by a loss or reduction of voluntary,emotional and other facial expressions,and usually appears bilaterally and symmetrically.Factors associated with hypomimia in PD have been extensively studied recently,including basal ganglia dysfunction,facial emotion recognition deficit,and cognitive impairment,but the specific pathophysiological mechanism is still unclear.Hypomimia strongly correlates with the progression of PD,so scientific quantification and evaluation of hypomimia will be of great significance to the diagnosis and treatment of PD.Besides that,there is still controversy over its treatment plan.We reviewed the latest developments in clinical presentations,pathogenesis and treatment of hypomimia in PD.