温针疗法联合西药治疗溃疡性结肠炎的疗效观察

Efficacy Observation of Needle Warming Therapy Combined with Western Medication for Ulcerative Colitis

目的观察调脾胃升降温针疗法联合西药治疗溃疡性结肠炎的临床疗效。方法将94例溃疡性结肠炎患者随机分为对照组和联合组,每组47例。对照组服用西药美沙拉嗪肠溶片治疗,联合组在对照组治疗基础上行调脾胃升降温针法治疗。观察两组治疗前后血清白细胞介素(IL)-6、IL-17、转化生长因子(TGF)-β1含量,中医证候积分变化,外周血辅助T细胞17(Th17)和调节性T细胞(Treg)比例以及结肠黏膜STAT3蛋白表达情况。比较两组临床疗效。结果治疗后两组患者各项中医证候积分均下降(P<0.05),且联合组低于对照组(P<0.05)。联合组疗效分级情况明显优于对照组(P<0.05);联合组总有效率高于对照组(P<0.05)。治疗后,两组患者血清IL-6、IL-17含量均降低(P<0.05),且联合组明显低于对照组(P<0.05);两组患者血清TGF-β1含量均升高(P<0.05),且联合组明显高于对照组(P<0.05);两组Th17细胞比例均降低(P<0.05),且联合组明显低于对照组(P<0.05);两组Treg细胞比例均升高(P<0.05),且联合组明显高于对照组(P<0.05);联合组结肠黏膜STAT3蛋白阴性表达率明显高于对照组(P<0.05)。结论调脾胃升降温针疗法联合西药治疗溃疡性结肠炎疗效较好,可能通过调节IL-6/STAT3信号通路纠正Th17/Treg平衡从而降低炎症因子含量。

Objective To observe the clinical efficacy of needle warming therapy plus Western medication to regulate the ascending and descending function of the spleen and stomach in treating ulcerative colitis(UC).Method Ninety-four UC patients were randomized into a control group and an integration group,with 47 cases in each group.The control group took Mesalazine enteric-coated tablets for treatment,and the integration group received additional needle warming therapy to regulate the ascending and descending function of the spleen and stomach.Before and after the treatment,the contents of serum interleukin(IL)-6,IL-17,and transforming growth factor(TGF)-β1,symptom scores of traditional Chinese medicine(TCM),the rates of T-helper cells(Th17)and regulatory T cells(Treg),and the expression of STAT3 protein in the peripheral blood were observed for the two groups.The clinical efficacy was also compared.Result After the treatment,the TCM symptom scores dropped in both groups(P<0.05)and were lower in the integration group than in the control group(P<0.05).The efficacy grading result was better in the integration group than in the control group(P<0.05),and the total effective rate was higher in the integration group than in the control group(P<0.05).After the intervention,the contents of serum IL-6 and IL-17 declined in the two groups(P<0.05)and were lower in the integration group than in the control group(P<0.05).The serum TGF-β1 content increased in both groups after the treatment(P<0.05)and was significantly higher in the integration group than in the control group(P<0.05).The Th17 rate dropped in the two groups(P<0.05)and was markedly lower in the integration group than in the control group(P<0.05);the Treg rate increased in both groups(P<0.05)and was notably higher in the integration group than in the control group(P<0.05).The negative expression rate of STAT3 protein of colonic mucosa in the integration group was significantly higher than that in the control group(P<0.05).Conclusion The needle warming therapy plus Western medication to regulate the ascending and descending function of the spleen and stomach can produce satisfactory efficacy in treating UC.It may down-regulate the contents of inflammatory factors via modulating the IL-6/STAT3 signaling pathway and restoring the Th17/Treg balance.