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芒针配合中药治疗下肢动脉硬化闭塞症的疗效观察 被引量:4

Observations on the Efficacy of Elongated Needle Acupuncture plus Chinese Herbal Medicine for Lower Limb Arteriosclerosis Obliterans
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摘要 目的观察芒针配合中药治疗下肢动脉硬化闭塞症的临床疗效。方法选取下肢动脉硬化闭塞症患者102例,按照完全随机数字表法分为对照组和治疗组,每组51例。两组患者均行常规基础治疗,对照组采用温阳益气通脉方治疗,治疗组采用芒针配合温阳益气通脉方治疗。采用酶联免疫吸附试验法检测血清中总胆固醇(TC)、甘油三酯(TG)、神经元特异性烯醇化酶(NSE)水平;采用免疫荧光定量检测法检测血浆钙调神经磷酸酶(CaN)、钙调神经磷酸酶调节因子1(RCAN1)水平;采用粗大运动功能评估量表(GMFM)、北极星移动评价量表(NSAA)分别评价下肢动脉硬化闭塞症患者肢体运动情况。并比较两组治疗前后中医证候积分变化及临床疗效。结果两组治疗后TC、TG、NSE、RCAN1、CaN水平和中医证候积分较治疗前均降低,且治疗组低于对照组,差异有统计学意义(P<0.05)。两组治疗后GMFM、NSAA评分均升高,且治疗组高于对照组,差异有统计学意义(P<0.05)。治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。结论在常规基础治疗的基础上,芒针配合中药可显著改善下肢动脉硬化闭塞症患者的临床症状,改善患者肢体麻木感。 Objective To observe the clinical efficacy of elongated needle acupuncture plus Chinese herbal medicine for lower limb arteriosclerosis obliterans.Method One hundred and two patients with lower limb arteriosclerosis obliterans were enrolled and allocated,using a random number table,to control and treatment groups,with 51 cases in each group.Both groups received conventional basic treatment.The control group was given yang-warming,qi-reinforcing and vessel-unblocking prescription and the treatment group,elongated needle acupuncture plus yang-warming,qi-reinforcing and vessel-unblocking prescription.Serum total cholesterol(TC),triglyceride(TG)and neuron-specific enolase(NSE)levels were measured using enzyme-linked immunosorbent assay(ELISA).Calcineurin(CaN)and regulator of calcineurin 1(RCAN1)were measured using immunofluorescence assay.Limb motor function was assessed using the gross motor function measure(GMFM)and the North Star ambulatory assessment(NSAA)in the patients with lower limb arteriosclerosis obliterans.Pre-treatment and post--treatment TCM syndrome scores and post-treatment clinical effects were compared between the two groups.Result After treatment,TC,TG,NSE,RCAN1 and CaN levels and the TCM syndrome score decreased in the two groups compared with before and were lower in the treatment group than in the control group,and the differences were statistically significant(P<0.05).After treatment,the GMFM and NSAA scores increased in the two groups compared with before and were higher in the treatment group than in the control group,and the differences were statistically significant(P<0.05).The total efficacy rate was higher in the treatment group than in the control group with a statistically significant difference(P<0.05).Conclusion On the basis of conventional basic treatment,elongated needle acupuncture plus Chinese herbal medicine can markedly relieve the clinical symptoms and reduce limb numbness in patients with lower limb arteriosclerosis obliterans.
作者 张青天 仝光照 许志会 黄忠利 戴莹 ZHANG Qingtian;TONG Guangzhao;XU Zhihui;HUANG Zhongli;DAI Ying(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)
机构地区 石家庄市中医院
出处 《上海针灸杂志》 2022年第5期504-509,共6页 Shanghai Journal of Acupuncture and Moxibustion
基金 河北省中医药管理局科研计划项目(2020336)。
关键词 芒针 针药并用 动脉硬化闭塞症 粗大运动功能评估量表 北极星移动评价量表 Elongated needle acupuncture Acupuncture medication combined Arteriosclerosis obliterans Gross motor function measure North Star ambulatory assessment
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