替格瑞洛联合阿托伐他汀钙强化治疗急性冠脉综合征的临床疗效及其安全性

Clinical efficacy and safety of ticagrelor combined with atorvastatin calcium in the intensive treatment of acute coronary syndrome

目的观察替格瑞洛联合阿托伐他汀钙强化治疗急性冠脉综合征的临床疗效及其安全性。方法选取2019年1月—2021年1月乐平市人民医院收治的急性冠脉综合征患者70例,按照随机数字表法分为对照组与观察组,各35例。对照组予以氯吡格雷联合阿托伐他汀钙,观察组予以替格瑞洛联合阿托伐他汀钙,2组均持续用药6个月。比较2组临床疗效,C反应蛋白(CRP)、心肌肌钙蛋白T(cTnT)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD),不良反应发生率。结果观察组总有效率为97.14%,高于对照组的62.85%(χ^(2)=12.857,P<0.001)。治疗后,观察组CRP、cTnT低于对照组,LVEF高于对照组,LVEDD、LVESD小于对照组(P<0.01)。观察组不良反应总发生率为2.85%,低于对照组的31.41%(χ^(2)=10.057,P=0.002)。结论替格瑞洛联合阿托伐他汀钙强化治疗急性冠脉综合征的临床疗效确切,可有效改善患者心功能,缓解临床症状,且安全性较高。

Objective To analyze the clinical efficacy and safety of ticagrelor combined with atorvastatin calcium in the intensive treatment of acute coronary syndrome.Methods A total of 70 cases of patients with acute coronary syndrome were selected from January 2019 to January 2021 in Leping People’s Hospital,which were divided into control group and observation group according to the random number table method,35 cases in each group.The control group was given clopidogrel combined with atorvastatin calcium,and the observation group was given ticagrelor combined with atorvastatin calcium.Both groups were continuously treated for 6 months.Clinical efficacy,C-reactive protein(CRP),cardiac troponin T(c Tn T),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.14%,higher than 62.85%of the control group(χ^(2)=12.857,P<0.001).After treatment,CRP and c Tn T in the observation group were lower than those in the control group,LVEF was higher than that in the control group,and LVEDD and LVESD were less than those in the control group(P<0.01).The total incidence of adverse reactions in the observation group was 2.85%,lower than 31.41%in the control group(χ^(2)=10.057,P=0.002).Conclusion Ticagrelor combined with atorvastatin calcium have an exact clinical effect for acute coronary syndrome,which can effectively improve cardiac function and alleviate clinical symptoms,and with high safety.