新型冠状病毒肺炎合并消化系统疾病的研究进展

Research progress on COVID-19 combined with digestive system diseases

新型冠状病毒肺炎(corona virus disease 2019,COVID-19)是一种由严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)与血管紧张素转换酶2(ACE2)受体结合进入宿主靶器官后引起的急性呼吸道传染病。最新研究提出,COVID-19可能是一种全身性传染病和系统性炎症性疾病。在急性感染后的COVID-19患者中经常发现消化系统的症状和体征。目前尽管存在与冠状病毒相关的一些消化系统疾病(如胃肠道疾病、肝损伤、胰腺损伤等),但现有研究中关于COVID-19合并消化系统症状的发病机制仍不明确,相关指南和专家共识尚不足以进行临床诊治。因此深入了解新冠肺炎合并消化系统患者的临床表现、发病机制及预后极其重要。

The corona virus disease 2019(COVID-19)is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-COV-2)after binding to angiotensin converting enzyme 2(ACE2)receptor into the host. Recent research suggests that COVID-19 may be a systemic infectious disease and systemic inflammatory disease. Signs and symptoms of the digestive system are often found in COVID-19 patients following acute infection. Although there are some coronavirus-related digestive diseases(such as gastrointestinal diseases,liver injury,pancreatic injury etc.),the pathogenesis of COVID-19 combined with digestive symptoms in existing studies is still unclear,and relevant guidelines and expert consensus are not sufficient for clinical diagnosis and treatment. Therefore,it is extremely important to have an in-depth understanding of the clinical manifestations,pathogenesis and prognosis of patients with COVID-19 complicated with digestive system.