子宫内膜厚度联合雌孕激素预测异常子宫出血患者内膜恶性病变的价值探讨

The Value of Endometrial Thickness Combined with Estrogen and Progesterone in Predicting Endometrial Malignancy in Patients with Abnormal Uterine Bleeding

目的:探究子宫内膜厚度联合雌孕激素预测异常子宫出血患者内膜恶性病变的价值。方法:将异常子宫出血病例作为此次研究的主要对象(收治时间在2019年1月—2020年12月),一共选取200例,另选择同期100例月经正常患者作为对照组,首先分析异常子宫出血患者内膜恶性病变情况,并对不同病变情况的子宫内膜厚度进行比较,以明确其相关性;再分析不同类型子宫内膜雌孕激素受体阳性率、不同类型异常子宫出血的性激素水平。结果:200例异常子宫出血患者中,内膜恶性病变所占比18.00%,良性病变所占比82.00%;而两组子宫内膜厚度相比较,恶性病变子宫内膜厚度明显高于良性病变(P<0.05);在不同类型子宫内膜雌孕激素受体阳性率中,除有排卵型功血外,其他类型异常子宫出血的ER、PR阳性率均高于对照组(P<0.05);在异常子宫出血患者中,除有排卵型功血患者外,其他类型患者的雌激素水平均高于对照组,两两比较,组间存在差异性(P<0.05);而有排卵型功血孕激素水平则明显高于对照组(P<0.05)。结论:对于异常子宫出血患者而言,分析其子宫内膜厚度联合雌孕激素指标,能够明确其内膜恶性病变情况,为后期治疗提供重要参考依据。

Objective:To explore the value of endometrial thickness combined with estrogen and progesterone in predicting endometrial malignancies in patients with abnormal uterine bleeding.Methods:Cases of abnormal uterine bleeding were selected as the main object of this study(admission period from January 2019 to December 2020), a total of 200 cases were selected, and another 100 patients with normal menstruation were selected as the control group during the same period.First, analyze the endometrial malignant lesions of patients with abnormal uterine bleeding, and compare the endometrial thickness of different lesions to clarify their correlation;then analyze the positive rates of different types of endometrial estrogen and progesterone receptors and different types of abnormal uterine bleeding the level of sex hormones.Results:Among 200 patients with abnormal uterine bleeding, endometrial malignant lesions accounted for 18.00% and benign lesions accounted for 82.00%. Compared with the endometrial thickness of the two groups, the endometrial thickness of malignant lesions was significantly higher than that of the benign lesions(P<0.05).Among the positive rates of different types of endometrial estrogen and progesterone receptors, except for ovulatory dysfunctional uterine bleeding, the positive rates of ER and PR of other types of abnormal uterine bleeding were higher than those of the control group(P<0.05).In patients with abnormal uterine bleeding, except those with ovulatory dysfunctional uterine bleeding, the estrogen levels of other types of patients were higher than those of the control group. Comparing pairwise, there was differences between the groups(P<0.05);while there was ovulation type.The content of progesterone in dysfunctional uterine blood was significantly higher than that in the control group(P<0.05).Conclusion:For patients with abnormal uterine bleeding, analysis of their endometrial thickness combined with estrogen and progesterone indicators can clarify their endometrial malignant lesions, which is the later stage, treatment provides an important reference basis.