初诊T2DM患者血NOV/CCN3、Nesfatin-1水平与胰岛素抵抗的关系

Relationship between serum Nov/CCN3,nesfatin-1 levels and insulin resistance in newly diagnosed T2DM patients

目的:探讨初诊2型糖尿病(T2DM)患者血清NOV/CCN3和Nesfatin-1水平变化及其与胰岛素抵抗、肥胖和其它代谢指标的关系。方法:随机选择来自佳木斯大学附属第一医院初诊T2DM患者,分为T2DM肥胖组30例、T2DM非肥胖组30例,随机选取同一时间的健康体检者,为健康对照组30例,用ELISA法检测血清NOV/CCN3及Nesfatin-1水平。结果:T2DM肥胖组的体重、体质量指数(BMI)、腰围(WC)、臀围(HC)水平高于T2DM非肥胖组和健康对照组,差异有统计学意义(P<0.05);在T2DM肥胖组、T2DM非肥胖组及健康对照组中空腹血糖(FPG)、空腹胰岛素(Fins)、糖化血红蛋白(Hb A1c)、HOMA-IR、甘油三酯(TG)、胆固醇(TC)、NOV/CCN3和Nesfatin-1水平依次降低,差异有统计学意义(P<0.05);Pearson与Spearman相关性分析提示NOV/CCN3和Nesfatin-1与体质量、BMI、腰臀比(WHR)、FPG、FIns、Hb A1c、TG、TC和HOMA-IR、HOMA-β有相关性(P<0.05);血清NOV/CCN3与Nesfatin-1呈正相关(P<0.05)。结论:初诊T2DM患者血清NOV/CCN3和Nesfatin-1水平升高;NOV/CCN3与Nesfatin-1呈正相关;NOV/CCN3及Nesfatin-1均与BMI、HOMA-IR呈正相关,提示这两种因子可能与2型糖尿病及肥胖的发生发展密切相关。

Objective:To investigate the changes of serum Nov/CCN3 and nesfatin-1 levels in newly diagnosed type 2 diabetes mellitus(T2DM)and their relationship with insulin resistance,obesity and other metabolic indexes.Method:a total of 30 newly diagnosed T2DM patients from the First Affiliated Hospital of Jiamusi University were randomly divided into T2DM obesity group(30 cases)and T2DM non obesity group(30 cases).Healthy subjects at the same time were randomly selected as healthy control group(30 cases).The serum levels of Nov/CCN3 and nesfatin-1 were detected by ELISA.Results:the levels of body weight,body mass index(BMI),waist circumference(WC),hip circumference(HC)in T2DM obese group were higher than those in T2DM non obese group and healthy control group(P<0.05);The levels of fasting blood glucose(FPG),fasting insulin(fins),glycosylated hemoglobin(Hb A1c),HOMA-IR,triglyceride(TG),cholesterol(TC),Nov/CCN3 and nesfatin-1 were decreased in T2DM obese group,T2DM non obese group and healthy control group(P<0.05);Pearson and Spearman correlation analysis showed that Nov/CCN3 and nesfatin-1 were correlated with body weight,BMI,WHR,FPG,fins,Hb A1c,TG,TC,HOMA-IR and HOMA-β(P<0.05);serum Nov/CCN3 was positively correlated with nesfatin-1(P<0.05).Conclusion:the serum levels of Nov/CCN3 and nesfatin-1 are increased in newly diagnosed T2DM patients;Nov/CCN3 is positively correlated with nesfatin-1;Nov/CCN3 and nesfatin-1 are positively correlated with BMI and HOMA-IR,suggesting that these two factors may be closely related to the occurrence and development of type 2 diabetes and obesity.