培哚普利对原发性高血压合并慢性心力衰竭患者疗效、血管内皮活性因子及心功能的影响

Effect of Perindopril on Therapeutic Effect,Cardiac Function and Inflammatory Factors in Patients with Essential Hypertension Complicated with Chronic Heart Failure

目的探讨培哚普利对原发性高血压合并慢性心力衰竭患者疗效、血管内皮活性因子及心功能的影响。方法选取2019年1月至2020年11月在鞍山市中心医院接受治疗的原发性高血压合并慢性心力衰竭患者80例作为研究对象,采用随机数字表法分为观察组与对照组,各40例。对照组采用氢氯噻嗪治疗,观察组在对照组基础上加用培哚普利治疗,比较两组心功能、血管内皮活性因子、炎症介质及治疗效果。结果治疗后,观察组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)低于对照组,一氧化氮(NO)、左室射血分数(LVEF)高于对照组,血栓素B_(2)(TXB_(2))、肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)低于对照组,差异有统计学意义(P<0.05)。观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。结论氢氯噻嗪治疗基础上,联用培哚普利能够显著提升疗效,减轻炎症反应,促进血管内皮细胞损伤修复,从而改善患者心功能。

Objective To analyze the effect of perindopril combined with hydrochlorothiazide in the treatment of essential hypertension and chronic heart failure.Methods A total of 80 patients with essential hypertension and chronic heart failure treated in Anshan Central Hospital from January 2019 to November 2020 were randomly divided into 2 groups,40 cases in each group.The control group was treated with hydrochlorothiazide,and the study group was treated with perindopril on the basis of hydrochlorothiazide.The therapeutic effect,cardiac function,vascular endothelial active factor and inflammatory factor levels of the 2 groups were compared.Results After treatment,the left ventricular end systolic diameter(LVESD)and left ventricular end diastolic diameter(LVEDd)of the study group were lower than those of the control group,the nitric oxide(no)and left ventricular ejection fraction(LVEF)of the study group were higher than those of the control group,the levels of thromboxane B_(2)(TXB_(2)),tumor necrosis factor-α(TNF-α),endothelin-1(ET-1),high sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)of the study group were lower than those of the control group,the difference was statistically significant(P<0.05).The treatment effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion On the basis of hydrochlorothiazide treatment,perindopril can significantly improve the curative effect of patients,reduce the inflammatory reaction of patients,promote the repair of vascular endothelial cell damage,and improve the heart function of patients.