盐酸溴己新联合酚妥拉明治疗小儿肺炎患儿的临床疗效

Clinical Study of Bromohexoxin Hydrochloride Combined with Phentolamine in the Treatment of Children with Pneumonia

目的探讨盐酸溴己新联合酚妥拉明治疗小儿肺炎患儿的临床疗效。方法选取2019年7月至2020年7月大连市中心医院收治的108例肺炎患儿作为研究对象,按随机数字表法分为对照组(n=54)和观察组(n=54)。患儿均在明确诊断后给予积极的对症治疗,对照组在此基础上给予盐酸溴己新治疗,观察组在对照组基础上联合酚妥拉明治疗。比较两组临床疗效、血清指标、症状改善时间以及血气指标情况。结果与对照组比较,观察组治疗有效率更高(P<0.05);治疗后,与对照组比较,观察组白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)水平更低(P<0.05);与对照组比较,观察组肺部湿啰音消失时间、退热时间、咳嗽消失时间及白细胞恢复正常时间更短(P<0.05);治疗后,与对照组比较,观察组动脉血氧分压(PaO_(2))及血氧饱和度(SaO_(2))指标更高(P<0.05),动脉血二氧化碳分压(PaCO_(2))指标更低(P<0.05)。结论与单用盐酸溴己新比较,盐酸溴己新与酚妥拉明联合治疗肺炎患儿效果更为显著,可以显著降低血清炎症介质,缓解临床症状,改善血气指标,有利于促进患儿康复。

Objective To explore the clinical efficacy of bromohexoxin hydrochloride combined with phentolamine in the treatment of children with pneumonia and its effect on serum inflammatory indexes and blood gas indexes.Methods A total of108 cases of pneumonia admitted to Dalian Central Hospital from July 2019 to July 2020 were selected as the research objects and were randomly divided into a control group(n=54)and an observation group(n=54).Both groups received active symptomatic treatment after definite diagnosis.The control group was treated with bromhexin hydrochloride alone,and the study group was treated with phentolamine based on the control group.The clinical efficacy,serum indexes,symptom improvement time and blood gas indexes of the 2 groups were observed and analyzed.Results Compared with the control group,the clinical efficacy of the observation group was higher(P<0.05);compared with the control group,the levels of IL-6,IL-17,TNF-αand hs-CRP in the control group were lower(P<0.05);compared with the control group,the disappearance time of pulmonary moist rales,fever,cough and the recovery time of leukocytes in the observation group were shorter(P<0.05);compared with the control group,the indexes of PaO_(2) and SaO_(2) in the observation group were higher(P<0.05).PaCO_(2) index was low(P<0.05).Conclusion Compared with bromhexin hydrochloride alone,bromhexin hydrochloride combined with phentolamine has more significant effect in the treatment of children with pneumonia,which can significantly reduce serum inflammatory factors,relieve clinical symptoms,improve blood gas index,and promote the rehabilitation of children.