摘要
神经退行性疾病是一类可导致感觉丧失、运动功能丧失和记忆衰竭等症状的难治性疾病,传统治疗方法虽能延缓疾病进展,但局限性明显。而神经干细胞移植作为一种潜在的新型治疗方式能够有效促进神经细胞的功能恢复及组织再生,在神经退行性疾病的治疗应用方面前景广阔。因此,本文通过对神经干细胞的现有来源及其在神经退行性疾病治疗中的研究进展进行综述,以期为神经干细胞移植在神经退行性疾病治疗中的应用提供新的思路。
Eurodegenerative diseases are refractory diseases that can cause symptoms such as loss of sensation,loss of motor function and memory failure.Although traditional treatment method can delay the progress of such diseases,they have obvious limitations.A potential new treatment method involving neural stem cell transplantation can effectively promote the functional recovery and tissue regeneration of nerve cells,and provides a promising treatment for neurodegenerative diseases.Therefore,this paper reviews the existing sources of neural stem cells and research progress using these cells in the treatment of neurodegenerative diseases,and provides the foundation and direction for further research and application of neural stem cell transplantation in neurodegenerative diseases.
作者
郭文文
赵亚
白敏
张延英
王颖花
汪永锋
师长宏
GUO Wenwen;ZHAO Ya;BAI Min;ZHANG Yanying;WANG Yinghua;WANG Yongfeng;SHI Changhong(Gansu University of Chinese Medicine,Lanzhou 730000,China;Laboratory Animal Center,Air Force Military Medical University,Xi’an 710032;Gansu University of Chinese Medicine/Gansu Engineering Laboratory for Quality Standardization of Authentic Medicinal Materials in Gansu Province/Provincial Key Laboratory of Pharmaceutical Chemistry and Quality Research in Gansu Province/Gansu Experimental Animal Industry Technology Center,Lanzhou 730000;Yan’an University,Yan’an 716000)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2022年第2期274-282,共9页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(81760828)
甘肃省中医药管理局科研课题(GZK-2019-26)
甘肃省自然科学基金(20JR5RA186)
陕西省创新能力支持计划(2021PT-037)
军队实验动物专项课题(SYDW(2018)01)。
关键词
神经干细胞
神经退行性疾病
神经分化
神经营养因子
neural stem cells
neurodegenerative disease
nerve differentiation
neurotrophic factors
