肠道菌群调节治疗阿尔茨海默病研究进展

Research progress of regulating intestinal flora in the treatment of Alzheimer's disease

阿尔茨海默病(AD)是一种常见的以短期和长期记忆丧失、决策能力受损、健忘和认知障碍为特征的与年龄高度相关且呈进行性改变的神经退行性疾病。AD的发病和治疗机制尚未完全明确。近年研究发现,肠道菌群与宿主的行为和认知功能密切相关,而肠道菌群多样性失衡可诱发神经系统疾病;因此,调节肠道菌群可能成为干预AD发病与进展的新靶点。本文从肠道菌群的定义及其作用、肠道菌群与AD的关系、通过不同治疗方法调节肠道菌群干预AD的研究进展等方面进行综述。

Alzheimer's disease(AD)is one of the most common neurodegenerative diseases with highly age-related and progressive changes,it is characterized by short-term and long-term memory loss,impaired decision-making ability,amnesia and cognitive impairment.The pathogenesis and treatment mechanism of AD have not been fully clarified.Recent research found that the intestinal flora is closely related to the behavior and cognitive function of the host,and the imbalance of intestinal flora diversity can induce nervous system diseases.Therefore,regulation of intestinal flora may be a new target for interventing the pathogenesis and progression of AD.This paper reviews the definition and function of intestinal flora,the relationship between the intestinal flora and AD,intervention of AD by regulating intestinal flora through different treatment methods.