硫酸氨基葡萄糖联合复方骨肽注射液治疗膝骨关节炎的临床疗效及对免疫功能的影响

Clinical effect of glucosamine sulfate combined with compound osteopeptide injection in treatment of knee osteoarthritis and its influence on immunologic function

目的:探讨硫酸氨基葡萄糖联合复方骨肽注射液治疗膝骨关节炎(KOA)的临床疗效。方法:选取某院收治的KOA患者130例,按照随机数字表法将患者分为对照组和研究组,每组65例。对照组采用肌内注射复方骨肽注射液治疗,研究组则在对照组的基础上联合硫酸氨基葡萄糖治疗,比较2组患者临床疗效、膝关节评分(WOMAC、ISOA、VAS评分)、炎症因子(IL-6、IL-17、TNF-α)水平、免疫功能指标(CD4^(+)、CD8^(+))、不良反应及疼痛复发率。结果:研究组临床疗效为92.31%,高于对照组的78.46%,差异有统计学意义(P<0.05);治疗4周后,研究组患者IL-6、IL-17、TNF-α、CD8+水平及WOMAC、ISOA、VAS评分分别为(32.36±3.45)pg/mL、(14.64±0.72)pg/mL、(39.48±8.51)pg/mL、(14.21±3.64)%及(43.94±10.53)分、(3.27±0.23)分、(2.11±0.20)分,均低于对照组,CD4+水平(38.86±4.85)%高于对照组,差异有统计学意义(P值均<0.05);研究组不良反应发生率(24.62%)低于对照组(9.23%),差异有统计学意义(P<0.05);研究组患者第6月时膝关节疼痛复发率(10.77%)低于对照组(24.62%),差异有统计学意义(P<0.05)。结论:硫酸氨基葡萄糖联合复方骨肽注射液治疗KOA可减轻炎症反应,临床疗效显著,且不良反应发生率及膝关节疼痛复发率均较低,具有较好的临床应用价值。

Objective:To investigate the effect of glucosamine sulfate combined with compound osteopeptide injection in the treatment of Knee Osteoarthritis(KOA).Methods:A total of 130 patients with KOA treated in a hospital were enrolled and randomly divided into a control group(n=65)and an observation group(n=65).The control group was intravenously injected with compound osteopeptide injection,while the observation group was treated with glucosamine sulfate on the basis of the control group.Clinical efficacy,knee scores,expression level of inflammation,immune factors,incidence of adverse reactions and recurrence rate of knee pain were compared between the two groups.Results:The total effective rate of the observation group(92.31%,60/65)was higher than that of the control group(78.46%,51/65)(P<0.05).The levels of IL-6,IL-17,TNF-α,CD8+and the scores of WOMAC,ISOA and VAS in the observation group(32.36±3.45 pg/mL,14.64±0.72 pg/mL,39.48±8.51 pg/mL,14.21±3.64%,43.94±10.53 points,3.27±0.23 points,2.11±0.20 points)were lower than those of the control group(48.62±4.23 pg/mL,19.04±0.81 pg/mL,56.49±8.90 pg/mL,16.92±4.26%,52.61±10.52 points,7.45±0.38 points,4.64±0.17 points)(P<0.05),while the level of CD4^(+)(38.86±4.85%)was higher than that in the control group(14.64±0.72%)(P<0.05).The total incidence of adverse reactions in the observation group(24.62%)was lower than that in the control group(9.23%)(P<0.05).By the 6th month,the recurrence rate of knee pain in the observation group(10.77%)was lower than that in the control group(24.62%)(P<0.05).Conclusion:Glucosamine sulfate combined with compound osteopeptide injection in the treatment of KOA can effectively reduce patients'inflammatory response and improve the patient's immunologic function.It's clinical effect is significant on the recovery of knee joint function,with low rate of adverse reaction and recurrence rate of knee joint pain.So it has good clinical application value.