摘要
神经母细胞瘤(neuroblastoma,NB)是儿童常见的颅外恶性实体肿瘤,国际神经母细胞瘤分期系统(International Neuroblastoma Staging System,INSS)将NB分为Ⅰ~Ⅳ期和Ⅳs期,其中Ⅳs(或4S)期是NB的一个特殊分期,以高转移率和高自愈率为主要特点。临床上4S期NB总体预后较好,患儿5年总体生存率为84%~92%,5年无事件生存率约82%。但仍有少部分4S期NB患儿预后不佳,此类患儿往往伴有不利的预后因素,如MYCN基因扩增、染色体畸变等,本文将阐述4S期NB预后不良相关因素的研究进展。
Neuroblastoma is a common extracranial solid tumor in children.International Neuroblastoma Staging System(INSS)divided neuroblastoma into phaseⅠ-ⅣandⅣs(or 4S).And 4S stage neuroblastoma is a special state characterized by high rates of metastasis and spontaneous regression.Generally stage 4S neuroblastoma has favorable clinical outcomes with 5-year overall survival(OS)of 84%-92%and 5-year event-free survival(EFS)of 82%.However some individuals have such poor prognostic factors as MYCN amplification and chromosome aberration.This review focused upon poor prognostic factors of children with stage 4S neuroblastoma.
作者
王鹏程
董瑞
Wang Pengcheng;Dong Rui(National Children's Medical Center,Department of Oncological Surgery,Children's Hospital of Fudan University,Shanghai Key Laboratory of Birth Defects,Shanghai 201102,China)
出处
《临床小儿外科杂志》
CAS
CSCD
2022年第4期394-398,共5页
Journal of Clinical Pediatric Surgery
基金
国家自然科学基金(82072782)。
