Effect of metformin on miRNA expression in type 2 diabetic patients and potential targets

Objective To investigate the effect of metformin on the microRNA(miRNA)expression and screen potential target with network pharmacology analysis in patients with type 2 diabetes.Methods Fifteen patients with newly diagnosed type 2 diabetes admitted to our hospital were selected,who received metformin during hospitalization and after discharge.The expression of serum matrix metalloproteinase(MMP)-9,transforming growth factor(TGF)-β1,and myocardial fibrosis related miRNAs were compared before and 6 month after metformin treatment.