The correlation between post-allo-HSCT CMV infection and the difference affinity of donor HLA-type recognition of CMV antigen peptide in children

Objective To explore the correlation between the affinity while donor's HLA type recognizing different cytomegalovirus(CMV)antigen peptide and the occurrence of CMV infection after allogeneic hematopoietic stem cell transplantation(allo-HSCT)in children.Methods To investigate the relationship between CMV reactivation,CMV infection or CMV related tissue/organ diseases and the different HLA-type recognition antigen peptide of the donors,we retrospectively analyzed the clinical data of 146 children with CMV infection for 6 months since from the time they underwent transplantation in Wuhan Children's Hospital.