右佐匹克隆联合氟哌噻吨美利曲辛治疗胆汁反流性胃炎并睡眠障碍的疗效与安全性研究

Efficacy and safety of dexzopiclone combined with flupentixol and melitracen in the treatment of bile reflux gastritis complicated with sleep disorders

目的探讨右佐匹克隆联合氟哌噻吨美利曲辛治疗胆汁反流性胃炎(BRG)并睡眠障碍的疗效及安全性。方法将陕西省核工业二一五医院老年病科2018年1月至2019年4月收治的89例BRG并睡眠障碍患者作为研究对象,按随机数表法分为对照组44例和观察组45例,对照组患者给予雷贝拉唑联合右佐匹克隆治疗,观察组患者在对照组治疗基础上予以氟哌噻吨美利曲辛治疗,持续治疗8周。比较两组患者的治疗效果和不良反应发生情况;于治疗前及治疗8周后根据患者临床资料评估其临床症状评分,并使用匹兹堡睡眠质量指数量表(PSQI)和Epworth嗜睡量表(ESS)评估患者睡眠质量。结果观察组患者的治疗总有效率为95.56%,明显高于对照组的79.55%,差异具有统计学意义(P<0.05);治疗后,观察组患者的反流、胃灼烧、胸骨后疼痛等症状评分分别为(0.56±0.15)分、(0.61±0.17)分、(0.59±0.16)分,明显低于对照组的(0.88±0.20)分、(0.93±0.23)分、(0.91±0.21)分,差异均有统计学意义(P<0.05);治疗后,观察组患者的PSQI评分和ESS评分分别为(3.82±1.02)分、(3.03±0.85)分,明显低于对照组的(5.45±1.50)分、(4.28±1.21)分,差异均有统计学意义(P<0.05);观察组患者的总不良反应发生率为24.44%,略高于对照组的18.18%,但差异无统计学意义(P>0.05)。结论右佐匹克隆联合氟哌噻吨美利曲辛可提高胆汁反流性胃炎并睡眠障碍患者的治疗效果,改善患者睡眠质量,且安全性较高。

Objective To investigate the efficacy and safety of dexzopiclone combined with flupentixol and melitracen in the treatment of bile reflux gastritis(BRG)complicated with sleep disorders.Methods Eighty-nine patients with BRG and sleep disorders who were admitted to the Department of Geriatrics,215 Hospital of Nuclear Industry of Shaanxi Province from January 2018 to April 2019 were selected as the research subjects.They were divided into a control group(44 cases)and an observation group(45 cases)according to the random number table method.Patients in the control group were treated with rabeprazole combined with dexzopiclone.On the basis of the treatment in the control group,patients in the observation group were additionally treated with flupentixol and melitracen.Both groups were treated for 8 weeks of treatment.Therapeutic effects and the incidence of adverse reactions were compared between the two groups.Clinical symptoms were assessed according to the patients'clinical data before treatment and after 8 weeks of treatment.The Pittsburgh Sleep Quality Index(PSQI)and Epworth Sleepiness Scale(ESS)were used to evaluate the sleep quality.Results The total response rate of the observation group was significantly higher than that of the control group(95.56%vs 79.55%),and the difference was statistically significant(P<0.05).After treatment,the scores of reflux,heartburn,and retrosternal pain in the observation group were(0.56±0.15)points,(0.61±0.17)points,and(0.59±0.16)points,significantly lower than(0.88±0.20)points,(0.93±0.23)points,and(0.91±0.21)points in the control group(P<0.05).After treatment,PSQI score and ESS score of the observation group were(3.82±1.02)points and(3.03±0.85)points,significantly lower than(5.45±1.50)points and(4.28±1.21)points of the control group(P<0.05).The total incidence of adverse reactions in the observation group was 24.44%,slightly higher than 18.18%in the control group,but the difference was not statistically significant(P>0.05).Conclusion Dexzopiclone combined with flupentixol and melitracen can improve the therapeutic effects on bile reflux gastritis complicated with sleep disorders,and improve the patients'sleep quality,with high safety.