急诊治疗有机磷农药中毒应用解磷定注射液的效果分析

Analysis of the Effect of Jielinding Injection in the Emergency Treatment of Organophosphorus Pesticide Poisoning

目的探讨采用解磷定注射液对有机磷农药中毒患者完成急诊治疗后的临床效果。方法选取海门区人民医院2020年1—12月收治的140例有机磷农药中毒患者进行治疗研究,随机分为常规治疗组(采用常规急诊急救措施完成治疗)和联合治疗组(采用常规急诊急救措施+解磷定注射液完成治疗),各70例。比较两组患者抢救有效率、血清胆碱酯酶水平、自主呼吸恢复时间、意识苏醒时间、住院时间及不良反应(全身无力、恶心呕吐、头痛)总发生率。结果联合治疗组抢救有效率(100.00%)高于常规治疗组(90.00%),差异有统计学意义(χ^(2)=5.413,P<0.05)。治疗前,联合治疗组血清胆碱酯酶水平(12.25±1.35)U/L,与常规治疗组血清胆碱酯酶水平(12.49±1.52)U/L比较,差异无统计学意义(t=0.987,P>0.05);治疗后,联合治疗组血清胆碱酯酶水平(25.39±3.25)U/L高于常规治疗组血清胆碱酯酶水平(16.49±2.19)U/L,差异有统计学意义(t=19.000,P<0.05)。联合治疗组自主呼吸恢复时间(8.19±2.52)h、意识苏醒时间(9.59±1.25)h、住院时间(3.13±0.13)d均短于常规治疗组自主呼吸恢复时间(12.79±2.53)h、意识苏醒时间(13.25±1.35)h、住院时间(5.13±0.35)d,差异有统计学意义(t=10.777、16.643、44.817,P<0.05)。联合治疗组不良反应(全身无力、恶心呕吐、头痛)总发生率(2.86%)同常规治疗组(1.43%)比较,差异无统计学意义(χ^(2)=0.000,P>0.05)。结论解磷定注射液治疗有机磷农药中毒患者,患者抢救有效率、血清胆碱酯酶水平、自主呼吸恢复时间、意识苏醒时间、住院时间以及不良反应情况,均获得明显改善,可促进急诊治疗水平、预后水平双重提升。

Objective To explore the clinical effect of the use of Jielindingne Injection on patients with organophosphorus pesticide poisoning after completing the emergency treatment.Methods A total of 140 patients with organophosphorus pesticide poisoning admitted to Haimen People's Hospital from January to December 2020 were selected for treatment study.They were randomly divided into the conventional treatment group(treated with conventional emergency treatment measures)and the combined treatment group(treated with conventional emergency treatment measures+dephosphatation injection),with 70 cases in each group.The rescue effective rate,serum cholinesterase level,spontaneous breathing recovery time,consciousness recovery time,hospitalization time and total incidence of adverse reactions(systemic weakness,nausea and vomiting,headache)were compared between the two groups.Results The rescue effective rate(100.00%)of the combined treatment group was higher than that of the conventional treatment group(90.00%),and the difference was statistically significant(χ^(2)=5.413,P<0.05).Before treatment,the serum cholinesterase level of the combined treatment group(12.25±1.35)U/L,compared with(12.49±1.52)U/L in the conventional treatment group,the difference was not statistically significant(t=0.987,P>0.05);after treatment,serum cholinesterase of combined treatment group the enzyme level(25.39±3.25)U/L was higher than the serum cholinesterase level(16.49±2.19)U/L of the conventional treatment group,the difference was statistically significant(t=19.000,P<0.05).The combined treatment group breathed spontaneously recovery time(8.19±2.52)h,consciousness recovery time(9.59±1.25)h,hospitalization time(3.13±0.13)d were shorter than the routine treatment group's spontaneous breathing recovery time(12.79±2.53)h,consciousness recovery time(13.25±1.35)h,hospitalization time(5.13±0.35)d,the difference was statistically significant(t=10.777,16.643,44.817,P<0.05).The total incidence of adverse reactions(systemic weakness,nausea and vomiting,headache)in the combined treatment group(2.86%)compared with the conventional treatment group(1.43%),the difference was not statistically significant(χ^(2)=0.000,P>0.05).Conclusion After the effective application of Jielinding injection,the effective rate of rescue,serum cholinesterase level,spontaneous respiration recovery time,consciousness recovery time,hospitalization time and adverse reactions were observed,and the situation was significantly improved.It can promote both emergency treatment and prognosis of patients with organophosphorus pesticide poisoning.