上消化道出血患者应用卡络磺钠联合泮托拉唑治疗的临床研究

Clinical Study of Carlosulphonate Combined with Pantoprazole in the Treatment of Patients with Upper Gastrointestinal Bleeding

目的分析上消化道出血患者应用卡络磺钠联合泮托拉唑治疗的临床效果。方法选取2018年1月—2021年1月医院收治的50例上消化道出血患者,按数字奇偶法分为两组,即对照组25例,采用泮托拉唑治疗;观察组25例,采用卡络磺钠联合泮托拉唑治疗;比较两组止血效果、凝血系统变化。结果观察组止血效果总有效率(100.0%)高于对照组的76.0%,差异有统计学意义(χ^(2)=4.735,P=0.030);观察组止血时间、血压平稳时间、腹痛消失时间均短于对照组,差异有统计学意义(P<0.05)。观察组治疗后D-二聚体、纤维蛋白原(FIB)及凝血酶原时间(PT)低于对照组,活化部分凝血活酶时间(APTT)高于对照组,差异有统计学意义(P<0.05)。红细胞计数、血红蛋白含量及血小板计数表达高于对照组,差异有统计学意义(P<0.05)。两组治疗不良反应发生情况比较,差异无统计学意义(P>0.05)。结论上消化道出血患者应用卡络磺钠联合泮托拉唑治疗,止血效果好,能增加血红蛋白含量,改善患者凝血功能。

Objective To analyze the clinical effect of calorosulfonate combined with pantoprazole in the treatment of patients with upper gastrointestinal bleeding.Methods A total of 50 patients with upper gastrointestinal bleeding admitted to the hospital from January 2018 to January 2021 were selected and divided into two groups according to the digital parity method.25 cases in the control group were treated with pantoprazole.In the observation group,25 cases were treated with sodium calosulphonate combined with pantoprazole.Compare the hemostatic effect and the changes of coagulation system between the two groups.Results The total effective rate of hemostasis in the observation group was 100.0%higher than that of the control group 76.0%,and the difference was statistically significant(χ^(2)=4.735,P=0.030).The hemostasis time,blood pressure stabilization time,and abdominal pain disappearance time of the observation group were shorter than those of the control group,and the difference was statistically significant(P<0.05).After treatment in the observation group,D-dimer,fibrinogen(FIB)and prothrombin time(PT)were lower than those in the control group,the activated partial thromboplastin time(APTT)was higher than that of the control group,the difference was statistically significant(P<0.05).The red blood cell count,hemoglobin content and platelet count expression were higher than those of the control group,the difference was statistically significant(P<0.05).Comparison of the occurrence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion The treatment of patients with upper gastrointestinal hemorrhage with sodium calorosulfonate combined with pantoprazole has a good hemostatic effect,increases hemoglobin content,and improves the coagulation function of patients.