卵巢癌免疫逃逸机制的研究进展

Research advances in mechanism of immune escape in ovarian cancer

卵巢癌在女性生殖系统恶性肿瘤中死亡率居首位,传统的手术和化疗对其生存率提高有限,免疫治疗是目前充满潜力的肿瘤治疗方式,卵巢癌有效免疫治疗的前提是对其免疫逃逸机制全面深刻的理解。卵巢癌的免疫逃逸机制包括卵巢癌相关抗原无法被识别、抗原递呈细胞的抑制、肿瘤杀伤性免疫细胞的抑制、免疫抑制细胞的激活等。

Ovarian cancer has the highest mortality rate among all malignant tumors of the female reproductive system.The traditional surgery and chemotherapy have the limited effect for increasing its survival rate.Immunotherapy is full of potential for tumor treatment at present.The premise of effective immunotherapy for ovarian cancer is a comprehensive and profound understanding of its immune escape mechanism.The mechanisms of immune escape of ovarian cancer include failure to recognize ovarian cancer-associated antigens,suppression of antigen-presenting cells,suppression of tumor killer immune cells,activation of immunosuppressive cells,etc.