Parkin蛋白与人类疾病的关系及其天然产物调节作用

Parkin protein and human diseases and its regulatory effect of nature products

Parkin蛋白是一种E3泛素连接酶,在机体不同部位均有表达,结构多样。研究发现,Parkin蛋白功能障碍主要引起线粒体自噬异常,与人类诸多疾病发生、发展密切相关。目前尽管尚缺乏Parkin配体,但已有研究报道天然产物可通过调节Parkin蛋白功能而缓解疾病,且具有副作用小、疗效稳定、多途径作用、作用温和持久等优势。该文对Parkin蛋白结构功能,与人类疾病的关系及天然产物对Parkin的调节作用进行简要综述,提出当前研究存在的一些问题,并对未来研究方向进行展望。

Parkin protein,an E3 ubiquitin ligase,is expressed in different parts of the body and has diverse structures.The studies have found that Parkin protein dysfunction will mainly cause abnormal mitophagy,which is an important pathogenesis of the occurrence and development of many human diseases.At present,although there is a lack of Parkin ligand,it has been reported that nature products can relieve the disease by regulating the function of Parkin protein,and it has the advantages such as low side effects,stable curative effect,multi-pathway effect and mild and long-lasting effect.This paper briefly reviews the structure and function of Parkin protein,its relationship with human diseases and regulatory effects of nature products on Parkin protein.Furthermore,some problems in the current research are proposed,and the future research directions are prospected.