多发性骨髓瘤免疫微环境的研究进展

Research Progress of Immune Microenvironment in Multiple Myeloma

多发性骨髓瘤是一种以骨髓中单克隆浆细胞的恶性增殖为特征的血液系统肿瘤。骨髓微环境对骨髓瘤细胞的增殖与存活起到关键的支撑作用,其中大量免疫细胞处于免疫抑制状态是该疾病重要的发病机制之一。本文以近年来开展的骨髓瘤免疫微环境研究为基础,就目前多发性骨髓瘤免疫治疗手段、现存问题进行阐述,同时对免疫治疗未来发展方向提出思考和建议,为多发性骨髓瘤诊治研究领域的同道提供参考。

Multiple myeloma is one type of hematological malignancy,characterized by the proliferation and accumulation of monoclonal plasma cells in bone marrow.Bone marrow microenvironment plays a key supporting role in the proliferation and survival of myeloma cells,where a large number of immune cells exist but are functionally suppressed.Based on the studies of myeloma immune microenvironment in recent years,we summarize the recent advances and existing problems in the treatment of multiple myeloma and put forward some considerations and suggestions,to provide references for researchers in this field.