头颈部腺样囊性癌的临床特点及预后影响因素

Clinical Features and Prognostic Factors of Adenoid Cystic Carcinoma of Head and Neck

目的回顾性分析48例头颈部腺样囊性癌患者的临床及病理资料,筛选影响患者预后的临床及病理因素。方法以患者总生存率作为观察预后的主要指标,选择11个可能对患者生存预后产生影响的临床及病理因素作为观察指标,根据Cox模型对各指标进行量化赋值。Cox多因素回归分析各因素与患者总体生存率的关系。结果中位随访时间为33.5(1~98)月。患者的1、2、5年总生存率为95%、91%、87%。复发14(29.2%)例;出现远处转移患者22(45.8%)例。Cox回归分析显示:复发、远处转移及原发部位与头颈部腺样囊性癌患者总生存率相关(P<0.05)。结论腺样囊性癌是头颈部较为罕见的肿瘤,恶性程度较低。复发、远处转移及原发部位对患者预后影响较大。

Objective To retrospectively analyze the clinical and pathological data of 48 patients with adenoid cystic carcinoma of the head and neck and screen out related factors that affect the patient’s prognosis.Methods The overall survival rate of patients is used as the main indicator for observing prognosis.We selected 11 clinical and pathological factors as observation indicators that may have an impact on the survival and prognosis of patients.The relation between observation factors and the overall survival rate of patients was analyzed by Cox multivariate regression.Results The median follow-up time was 33.5(1-98)months.The 1-,2-and 5-years overall survival rates were 95%,91%and 87%.Local recurrence occurred in 14(29.2%)patients.Distant metastasis occurred in 22(45.8%)patients.Cox regression analysis showed that recurrence,distant metastasis and primary site were correlated with the overall survival rate of patients with head and neck adenoid cystic carcinoma(P<0.05).Conclusion Adenoid cystic carcinoma is a relatively rare tumor of the head and neck with a low degree of malignancy.However,recurrence,distant metastasis and primary site have relatively great impact on the prognosis of patients.