摘要
金属有机框架(MOFs)是一类由金属离子和有机配体通过配位反应自组装形成的特殊材料,具有生物相容性好、比表面积大、pH敏感度强等理化性质。进行修饰或改性后,可以制备出性能优良的复合纳米材料,在肿瘤治疗方面有着巨大的应用前景。本文主要基于MOFs及其衍生材料在肿瘤载药治疗、光动力治疗及免疫治疗中的应用进行综述。
Metal-organic frameworks(MOFs)are special materials formed by self-assembly of metal ions and organic ligands,with special physical and chemical properties,such as large specific surface area,excellent biocompatibility and strong pH sensitivity,etc.Through modification,they have synthesized nanomaterials with excellent performance,which have huge application prospects in treating tumors.This paper mainly reviews the properties of MOFs and their derived materials,and the application progress of MOFs in tumor drug-loaded therapy,photodynamic therapy and immunotherapy.
作者
郭阳
吴素清
温朝辉
GUO Yang;WU Suqing;WEN Zhaohui(Department of Neurology and Brain Ultrasound,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Ultrasound,Heze Municipal Hospital,Heze 274031,China)
出处
《肿瘤防治研究》
CAS
CSCD
2022年第5期472-477,共6页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金(51873052)。
关键词
金属有机框架
肿瘤
光动力治疗
免疫治疗
Metal-organic frameworks
Tumor
Photodynamic therapy
Immunotherapy
