摘要
利用微生物发酵技术,将葡萄籽以红酒酵母发酵得到葡萄籽发酵液,选用抗衰模式生物秀丽隐杆线虫,建立小鼠黑素瘤细胞美白模型,从细胞水平与分子水平层面探究葡萄籽发酵液在抗衰老和美白方面的功效作用,并对葡萄籽发酵液进行安全性评定。研究结果显示葡萄籽发酵液能够有效抵御衰老并抑制黑色素生成,具有抗衰、美白效果以及良好的安全性,具备成为化妆品功效原料的应用潜力。
As the largest byproducts of the grape processing industry, the development and utilization of grape seeds has become one of the urgent problems to be solved. Grape seeds are rich in active substances, which have the functions of anti-oxidation, anti-aging, anti-radiation and whitening. They can remove excessive oxygen free radicals produced by the body under oxidative stress conditions, and reduce the skin injury caused by external radiation and environmental pollution, which have a potential role in skin care. In this study, grape seeds were fermented using microbial fermentation technology with red wine yeast to obtain grape seed fermentation broth. The anti-aging model organism C.elegans was selected, and a mouse melanoma cell whitening model was established to explore the anti-aging and whitening effects of grape seeds from the cellular and molecular levels. Research results show that grape seed fermentation broth can effectively resist aging and inhibit melanin production, which has anti-aging and whitening effects. It also has good safety, and has the application potential as cosmetic functional raw materials. The by-products of grape processing have been reused, and its potential application value has been discovered, which is in line with the concept of green development.
作者
王冬冬
孙倩茹
王子文
方嘉璇
李萌
王昌涛
Dongdong Wang;Qianru Sun;Ziwen Wang;Jiaxuan Fang;Meng Li;Changtao Wang(Key Lab of Plant Resource Research and Development,College of Chemistry and Materials Engineering,Beijing Technology and Business University,Beijing 100048,China;Beijing Advanced Innovation Center for Food Nutrition and Human Health,Beijing Technology and Business University,Beijing 100048,China)
出处
《日用化学工业》
CAS
北大核心
2022年第5期545-552,共8页
China Surfactant Detergent & Cosmetics
关键词
葡萄籽
发酵技术
秀丽隐杆线虫
抗衰老
美白
安全性评价
grape seed
fermentation technology
C.elegans
anti-aging
whitening
safety evaluation