氟比洛芬酯超前镇痛用于无痛人工流产术对术中丙泊酚用量及凝血功能影响

Effects of fluorbillofenester used as preemptive analgesia during painless abortion of women on the dosage of propofol used and the coagulation function

目的:探究氟比洛芬酯超前镇痛用于无痛人工流产术中丙泊酚用量及受术者凝血功能的影响。方法:选取2018年12月-2020年12月在本院行无痛人工流产术300例,随机数字表法分为超前组和常规组各150例,两组均行常规麻醉诱导,超前组麻醉诱导前给予静脉注射氟比洛芬酯。比较两组血流动力学指标、术中镇静药物使用量及不良反应情况,并分别于术后6h、24h、48h复查凝血指标。结果:术中超前组丙泊酚用量(106.4±6.5mg)及次数(1.2±0.3次)低于常规组(145.4±7.6mg、2.1±0.5次),麻醉优良率(100.0%)优于对照组(92.0%)(均P<0.05)。术后6h、24h、48h两组凝血指标均无差异(P>0.05);超前组麻醉诱导前、手术5min、扩宫口时、负压吸引时、术毕时及术后15min时心率及平均动脉压均低于常规组,血氧饱和度高于常规组,总不良反应发生率(7.3%)低于常规组(15.3%)(均P<0.05)。结论:氟比洛芬酯超前镇痛用于无痛人工流产术效果较好,可有效降低受术者术中镇静药物的使用,且对凝血功能指标及血流动力学指标影响较小。

Objective:To explore the effects of fluorbillofenester used as preemptive analgesia during painless abortion of women on the dosage of propofol used and the coagulation function of women.Methods:300 women who wanted painless abortion were selected and were divided into two groups(150 cases in each group)by randomized digital tables from December 2018 to December 2020.Routine anesthesia induction was performed in these women.The women in the research group were given intravenous fluorbillofentones additionally before anesthesia induction.The hemodynamic indexes values,the dosages of sedative drugs used during abortion,and the rate of adverse reactions of the women were compared between the two groups.The levels of the coagulation index of the women in the two groups at 6 h,24 h,and 48 h were detected again.Results:The dosage of propofol(106.4±6.5 mg)and times of propofol used(1.2±0.3 times)of the women in the research group during abortion were significantly lower than those(145.4±7.6 mg and 2.1±0.5 times)of the women in the control group.The rate of excellent anesthesia efficacy(100.0%)of the women in the research group was significantly better than that(92.0%)of the women in the control group(all P<0.05).There were no significant differences in the coagulation indexes levels at postoperative 6 h,24 h,and 48 h of the women between the two groups(P>0.05).The values of heart rate and mean arterial pressure of the women in the research group before induction of anesthesia,at 5 min after abortion began,at dilation of cervix uteri,at vacuum aspiration,at completion of surgery,and at 15 min after abortion were significantly lower than those of the women in the control group.The value of oxyhemoglobin saturation of the women in the research group was significantly higher than that of the women in the control group.The total incidence of adverse reactions(7.3%)of the women in the research group was significantly lower than that(15.3%)of the women in the control group(all P<0.05).Conclusion:Fluorbilofen used as preemptive analgesia during painless abortion of women has good anesthesia effect,which can effectively reduce the dosage of sedative drugs used during abortion,and has little effect on the indicators of coagulation function and hemodynamic indicators of the women.