索利那新联合盆底生物反馈治疗女性重度膀胱过度活动症效果

Effect of solinacine combined with pelvic floor biofeedback for treating women with severe overactive bladder

目的:探讨索利那新联合盆底生物反馈治疗女性重度膀胱过度活动症(OAB)疗效。方法:选取2016年2月-2021年2月于本院诊治的重度OAB患者86例,按照患者个人意愿分为索利那新组(39例)与索利那新+生物反馈组(47例),比较患者治疗前后盆底肌力牛津分级评估(MOS)、膀胱过度活动症症状评分(OABSS)表、King健康问卷(KHQ)的评分变化。结果:与治疗前比较,两组治疗后1个月、3个月OABSS表各项评分及总评分均下降且索利那新+生物反馈组评分低于索利那新组(P<0.05);两组治疗后1个月、3个月MOS表评分均升高且索利那新+生物反馈评分高于索利那新组(P<0.05);两组治疗后1个月、3个月KHQ表评分均降低(P<0.05),治疗前、治疗后1个月与治疗前比较两组KHQ表评分无差异(P>0.05),治疗后3个月,索利那新+生物反馈组评分低于索利那新组(P<0.05)。索利那新+生物反馈组与索利那新组比较不良反应发生率(8.5%、7.7%)无差异(P>0.05)。结论:索利那新联合盆底生物反馈治疗可进一步缓解女性重度OAB临床症状,且未增加不良反应发生。

Objective:To explore the efficacy of solinacine combined with pelvic floor biofeedback for treating women with severe overactive bladder(OAB).Methods:A total of 86 women with severe OAB were selected as the research subjects from February 2016 to February 2021.According to the personal wishes of the women,these women were divided into group A(47 cases given solinacine combined with pelvic floor biofeedback treatment)and group B(39 cases given solinacin treatment).The changes of score evaluated by pelvic floor muscle strength assessment(MOS),bladder hyperactivity symptom score(OABSS),and King health questionnaire(KHQ)of the women in the two groups were compared between before and after treatment.Results:The scores of each item and total items of OABSS of the women in the two groups in 1 month and 3 months after treatment had decreased significantly,and which of the women in group A were significantly lower than those of the women in group B(P<0.05).The score of MOS of the women in the two groups in 1 month and 3 months after treatment had increased significantly,and which of the women in group A were significantly higher than those of the women in group B(P<0.05).The score of KHQ of the women in the two groups in 1 month and 3 months after treatment had decreased significantly(P<0.05).The score of KHQ of the women in the two groups in 1 month after treatment had no significant different from that before treatment(P>0.05),which of the women in group A in 3 months after treatment was significantly lower than that of the women in group B(P<0.05).There was no significant difference in the incidence of adverse reactions(8.5%vs.7.7%)of the women between the two groups(P>0.05).Conclusion:Solinacine combined with pelvic floor biofeedback for treating women with severe OAB can further alleviate their clinical symptoms without increasing their adverse reactions.