摘要
目的:探讨丹参酮联合促性腺释放激素激动剂(GnRH-a)垂体降调节在多囊卵巢综合征(PCOS)合并代谢障碍者冻融胚胎移植的临床效果。方法:将150例行冻融胚胎移植(FET)的PCOS合并代谢障碍患者分为丹参酮组、垂体降调节组和联合组,比较3组血清生殖激素和糖脂代谢指标水平,子宫内膜容受性以及临床妊娠结局。结果:3组基础血清生殖激素和糖脂代谢指标无差异(P>0.05)。联合组内膜转化日、FET移植前1天血清卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E;)和睾酮(T)水平明显低于丹参酮组和垂体降调节组(P<0.05);内膜转化日丹参酮组和联合组空腹血糖(FBG)、胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白(LDL)水平降低(P<0.05),联合组FBG、TC、TG和LDL水平显著低于丹参酮组(P<0.05);联合组ET日子宫内膜厚度、A型内膜占比以及临床妊娠率明显大于丹参酮组和垂体降调节组(P<0.05)。结论:丹参酮联合GnRH-a垂体降调节能进一步改善PCOS女性代谢异常,降低雄激素,提高子宫内膜容受性及改善妊娠结局。
Objective:To explore the clinical effect of tanshinone combined with GnRH-a pituitary down regulation for treating women with polycystic ovary syndrome(PCOS)during freeze thawing embryo transplantation.Methods:150 women with PCOS during freeze thawing embryo transplantation(FET)were divided into group A(women given polycystic only),group B(women given GnRH-a pituitary down regulation only),and group C(women given tanshinone combined with GnRH-a pituitary down regulation).The levels of serum reproductive hormone,and glucose and lipid metabolism index,the endometrial receptivity,and the clinical pregnancy outcomes of the women were compared among the three groups.Results:There were no significant different in the levels of serum basics reproductive hormone,and glucose and lipid metabolism index of the women among the three groups(P>0.05).The levels of serum follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E;),and testosterone(T)of the women on the endometrial transformation day and 1 day before FET in group C were significantly lower than those of the women in group A and group B(P<0.05).The levels of fasting blood glucose(FBG),cholesterol(TC),triglyceride(TG),and low density lipoprotein(LDL)of the women in group A and group C on the endometrial transformation day had decreased significantly(P<0.05),and the levels of FBG,TC,TG and LDL of the women in group C were significantly lower than those of the women in group B(P<0.05).The endometrial thickness,the ratio of endometrial type A,and the clinical pregnancy rate of the women in group C on the ET day were significantly higher than those of the women in group A and group B(P<0.05).Conclusion:Tanshinone combined with GnRH-apituitary down-regulation can further improve metabolic abnormalities of the women with PCOS,reduce their serum androgen level,increase their endometrial receptivity,and improve their pregnancy outcomes.
作者
张荣雪
仲纪祥
薛惠英
ZHANG Rongxue;ZHONG Jixiang;XUE Huiying(Huaian Maternal and Child Health Care Hospital,Jiangsu Province,223002)
出处
《中国计划生育学杂志》
2022年第2期383-386,390,共5页
Chinese Journal of Family Planning
基金
淮安市科技局立项(HAB202042)。
关键词
多囊卵巢综合征
代谢障碍
冻融胚胎移植
丹参酮
GnRH-a垂体降调节
Polycystic ovary syndrome
Metabolic disorders
Freeze thawing embryo transplantation
Tanshinone
GnRH-a pituitary down regulation