针灸联合克罗米芬治疗多囊卵巢综合征效果

Effects of acupuncture combined with clomid for treating women with polycystic ovary syndrome

目的:探讨针灸联合克罗米芬治疗多囊卵巢综合征(PCOS)效果.方法:选取2018年6月—2020年12月在本院和上海中医药大学附属曙光医院确诊的120例肝郁化火兼脾虚痰湿型PCOS患者,采取简单随机分组模式均分为观察组(针灸+口服克罗米芬片治疗)和对照组(口服克罗米芬片治疗).持续治疗3个月后,比较两组临床疗效、卵泡和子宫内膜发育、排卵和妊娠情况,记录不良反应发生情况.结果:治疗后,观察组总有效率(93.3%)高于对照组(80.0%),成熟卵泡直径(26.7±5.0mm)长于对照组(21.5±4.6mm),子宫内膜厚度(8.3±1.2mm)高于对照组(7.4±1.2mm),内膜形态A型率(60.0%)高于对照组(41.7%),排卵率(86.7%)和临床妊娠率(51.7%)高于对照组(66.7%、31.7%),未破裂卵泡黄素化综合征(1.7%)和卵巢过度刺激综合征(3.3%)发生率低于对照组(15.0%、16.7%)(均P<0.05),不良反应发生率(3.3%)与对照组(1.7%)无差异(P>0.05).结论:克罗米芬联合针灸治疗PCOS临床疗效更佳,更有利于改善患者妊娠结局.

Objective: To explore the effects of acupuncture combined with clomid for treating women with polycystic ovary syndrome(PCOS) on their pregnancy outcomes. Methods: A total of 120 women with PCOS of liver depression transforming fire and spleen deficiency and phlegm-dampness type were enrolled in this study and were divided into two groups by simple randomized grouping mode between June 2018 and December 2020. The women in the observation group were given acupuncture combined with oral clomiphene tablets, and the women in the control group were given oral clomiphene tablets. After 3 months of continuous treatment, the clinical curative effect, the development situations of follicle and endometrium, the ovulation, and the pregnancy of the women were compared between the two groups. The occurrence of adverse reactions of the women in both groups was recorded. Results: After treatment, the total effective rate(93.3%) of the women in the observation group was significantly higher than that(80.0%) of the women in the control group, the diameter of mature follicle(26.7±5.0 mm) of the women in the observation group was significantly longer than that(21.5±4.6 mm) of the women in the control group, and the endometrial thickness(8.3±1.2 mm) of the women in the observation group was significantly more than that(7.4±1.2 mm) of the women in the control group. The type A rate of endometrial morphology(60.0%) of the women in the observation group was significantly higher than that(41.7%) of the women in the control group, and the rates of ovulation(86.7%) and clinical pregnancy(51.7%) of the women in the observation group were significantly higher than those(66.7% and 31.7%) of the women in the control group. The incidences of unruptured follicular luteinization syndrome(1.7%) and the ovarian hyperstimulation syndrome(3.3%) of the women in the observation group were significantly lower than those(15.0% and 16.7%) of the women in the control group(all P<0.05), and the incidence of adverse reactions(3.3%) of the women in the observation group had no significant different from that(1.7%) of the women in the control group(P>0.05).Conclusion:Acupuncture combined with clomid for treating women with PCOS has better clinical efficacy,which is more conducive to improving the pregnancy outcomes of these women.