妊娠期高血压患者动脉血流动力学参数与胎儿心脏发育功能指标

Arterial hemodynamic parameters of uterine and the development indexes of fetal heart function of pregnant women with gestational hypertension

目的:研究妊娠期高血压动脉血流动力学参数对胎儿心脏发育的影响.方法:以2017年2月—2020年12月本院治疗的妊娠期高血压孕妇112例(病例组),正常妊娠孕妇112例为对照组,比较两组及不同严重程度妊娠期高血压孕妇动脉和胎儿脐动脉血流搏动指数(PI)、阻力指数(RI)以及胎儿心肌综合指数(Tei),分析病例组动脉血流动力学参数与胎儿Tei指数的相关性.结果:病例组子宫动脉PI(1.42±0.14),RI(0.55±0.13)、S/D值(2.65±0.26)、胎儿脐动脉PI(0.78±0.21),RI(0.48±0.21)、S/D值(2.52±0.17)均高于对照组,且妊娠期高血压、轻度子痫前期、重度子痫前期患者子宫动脉和胎儿脐动脉PI、RI、S/D值依次升高(均P<0.05);病例组胎儿左心室Tei(0.45±0.14)、右心室Tei(0.46±0.12)均高于对照组,左右心室Tei妊娠期高血压、轻度子痫前期、重度子痫前期依次升高(均P<0.05).相关性分析,妊娠期高血压孕妇子宫动脉、胎儿脐动脉PI、RI、S/D值与左右心室Tei指数呈现正相关(均P<0.05).结论:妊娠期高血压孕妇动脉血流动力学参数发生异常,对胎儿心脏发育功能产生不良影响.

Objective: To investigate the influence of the uterine arterial hemodynamic parameters of pregnant women with gestational hypertension on their fetal development indexes of heart function. Methods: 112 pregnant women with gestational hypertension were selected in research group, and 112 normal pregnancy were selected in control group from February 2017 to December 2020. The values of uterine arterial pulsatility index(PI) and resistance index(RI) of the women, and the values of fetal umbilical artery PI and RI, and the value of fetal myocardial composite index(Tei) were compared between the two groups. The correlation between the uterine arterial hemodynamic parameters of the women in the research group and their fetal Tei index was analyzed. Results: The values of uterine arterial PI(1.42±0.14), RI(0.55±0.13), and S/D(2.65±0.26) of the women, and the fetal umbilical artery PI(0.78±0.21), RI(0.48±0.21), and S/D(2.52±0.17) in the research group were all significantly higher than those in control group. The values of PI, RI, S/D of uterine artery and fetal umbilical artery of the women with gestational hypertension, the women with mild preeclampsia, and the women with severe preeclampsia had increased gradually(all P<0.05). The value of fetal left ventricular Tei(0.45±0.14) and right ventricular Tei(0.46±0.12) of the women in the research group were significantly higher than those of the women in the control group. The values of left and right ventricular Tei of the women with gestational hypertension, the women with mild preeclampsia, and the women with severe preeclampsia had increased gradually(all P<0.05). Correlation analysis showed that the values of PI, RI, S/D of uterine artery of the women and the fetal umbilical artery were positively correlated with the values of left and right ventricular Tei(all P<0.05). Conclusion: The hemodynamic parameters of uterine arterial of pregnant women with gestational hypertension are abnormal,which can lead to the adverse effect on their fetal heart development function.