女性生殖系统中细胞外基质蛋白Periostin研究进展

Research progress of Periostin in female reproductive system

Periostin是一种细胞外基质蛋白,在人体多种组织器官中都有表达,通过多种细胞因子和信号通路参与机体生理和病理的调节过程.近年来,Periostin被证实在女性生殖系统中发挥着重要作用.在子宫内膜中,表达受卵巢类固醇激素的调节,可以作为子宫内膜容受性的标志物,在胚胎着床、妊娠的进展中也发挥着重要作用.同时,Periostin参与子宫内膜异位症的调节,在子宫肌瘤、多囊卵巢综合征患者中高表达,在子宫内膜癌、宫颈癌、卵巢癌的侵袭转移中也发挥着重要的作用.本文对Periostin在女性生殖系统中表达及作用以及对妊娠影响的相关研究进行系统综述.

Periostin is an extracellular matrix protein, which is expressed in many tissues and organs of the human body and participates in the physiological and pathological regulation of the body through a variety of cytokines and signal pathways. In recent years, Periostin has been confirmed to play an important role in the female reproductive system. In the endometrium, the expression of Periostin is regulated by ovarian steroid hormones, and it can be used as a marker of endometrial receptivity, which also plays an important role in the progression of embryonic implantation and pregnancy. Meanwhile, Periostin is involved in the regulation of endometriosis, and which is highly expressed in the patients with uterine fibroids and polycystic ovary syndrome. Periostin plays an important role in the invasion and the metastasis of endometrial, cervical, and ovarian cancers. This article reviews the studies related to the expression and role of Periostin in the female reproductive system and its influences on the pregnancy of female systematically.