血清HK10、PIVKA-Ⅱ水平诊断卵巢癌及预测患者生存价值

Values of serum HK10 and PIVKA-Ⅱ levels for diagnosing and predicting the prognosis of ovarian cancer

目的:研究血清拮抗剂-Ⅱ诱导的蛋白质(PIVKA-Ⅱ)、激肽释放酶10(HK10)水平对卵巢癌的诊断及生存预测。方法:采用前瞻性研究,以本院2013年1月-2018年1月诊断进行治疗的卵巢癌患者156例作为研究对象,治疗后3年随访,生存101例、死亡55例;健康体检志愿者156例为对照组,比较两组及生存和死亡患者的血清HK10、PIVKA-Ⅱ水平并分析对卵巢癌的诊断及对患者生存预测效能。结果:观察组HK10(2.74±1.37 mg/L)、PIVKA-Ⅱ(35.21±1.95 U/L)水平均高于对照组(0.70±0.51 mg/L、18.60±1.96 U/L),生存患者HK10(2.10±0.77 mg/L)、PIVKA-Ⅱ(33.76±1.17 U/L)低于死亡患者(3.92±1.98 mg/L、37.87±1.01 U/L)(均P=0.000);HK10联合PIVKA-Ⅱ检测,诊断卵巢癌的曲线下面积为0.950,诊断临界值HK10、PIVKA-Ⅱ分别为2.74mg/L,35.20U/L;预测生存的曲线下面积为0.996,预测临界值HK10、PIVKA-Ⅱ分别为3.94mg/L,37.96U/L。结论:血清HK10、PIVKA-Ⅱ水平对卵巢癌的诊断及术后3年死亡预测均有较高的临床价值。

Objective:To study the value of serum HK10and PIVKA-Ⅱlevels for diagnosing and predicting the prognosis of ovarian cancer of patients.Methods:In this prospective study,156patients with ovarian cancer were selected in study group from January 2013-January 2018.During 3years followed up after treatment,101patients in the study group who survived were included in group A,and other 55patients who died were included in group B.156volunteers who underwent physical examination during the same period were selected in control group.The levels of serum HK10and PIVKA-Ⅱof the patients were compared between the study group and the control group,and between group A and group B.The serum HK10and PIVKA-Ⅱlevels for diagnosing and predicting the prognosis of ovarian cancer of the patients were analyzed.Results:The levels of HK10(2.74±1.37mg/L)and PIVKA-Ⅱ(35.21±1.95 U/L)of the patients in the study group were significantly higher than those(0.70±0.51mg/L and 18.60±1.96U/L)of the patients in the control group.The levels of HK10(2.10±0.77mg/L)and PIVKA-Ⅱ(33.76±1.17U/L)of the patients in group A were significantly lower than those(3.92±1.98mg/L and 37.87±1.01U/L)of the patients in group B(all P=0.000).The area under of the curve of the levels of HK10combined with PIVKA-Ⅱfor diagnosing ovarian cancer was 0.950,and the critical value of HK10and PIVKA-Ⅱfor diagnosing ovarian cancer were 2.74mg/L and 35.20U/L,respectively.The area under of the curve of the levels of HK10combined with PIVKA-Ⅱfor predicting survival of the patients was 0.996.The critical values of HK10and PIVKA-Ⅱfor predicting survival of the patients were 3.94mg/L and 37.96U/L,respectively.Conclusion:The diagnosis of ovarian cancer and the predicting death of the patients with ovarian cancer are significantly correlated with their serum HK10and PIVKA-Ⅱlevels,which can be used as an important basis for diagnosing and evaluating the prognosis of ovarian cancer of the patients.