醋酸曲普瑞林对多囊卵巢综合征不孕患者血清SHBG、ApoB/ApoA1、AGEs作用

Effect of tripraline acetate for treating infertile patients with polycystic ovary syndrome on their levels of serum sex hormone binding globulin and advanced glycosylation end products,and their value of apolipoprotein B/apolipoprotein A1

目的:探讨醋酸曲普瑞林治疗多囊卵巢综合征不孕症患者血清性激素结合球蛋白(SHBG)、载脂蛋白B/载脂蛋白A1比值(ApoB/ApoA1)及晚期糖基化终产物(AGEs)变化。方法:选择2019年1月-2020年1月本院治疗的多囊卵巢综合征不孕症患者125例,随机数表法分为两组,分别给予给予枸橼酸治疗(氯米芬组,62例)或醋酸曲普瑞林治疗(曲普瑞林组,63例)。比较两组临床疗效、血清SHBG、ApoB/ApoA1、AGEs、睾酮(T)、雌二醇你(E_(2))、黄体生成素(LH)、卵泡刺激素(FSH)、排卵日子宫内膜厚度、成熟卵泡数、周期排卵率及不良反应。结果:治疗后曲普瑞林组总有效率(90.5%)高于氯米芬组(71.0%)(P<0.05);两组血清SHBG均升高、ApoB/ApoA1及AGEs均下降且曲普瑞林组变化幅度高于氯米芬组,两组血清T、E_(2)、LH及FSH水平均下降且曲普瑞林组低于氯米芬组,排卵日子宫内膜厚度、成熟卵泡数曲普瑞林组均高于氯米芬组(均P<0.05);治疗期间两组不良反应发生率(12.7%、8.1%)及治疗费用比较无差异(P>0.05)。结论:醋酸曲普瑞林治疗多囊卵巢综合征不孕症可有效改善患者血清SHBG、ApoB/ApoA1及AGEs水平,效果更佳且安全。

Objective:To study the changes of the levels of serum sex hormone binding globulin(SHBG)and advanced glycosylation end products(AGEs),and the value of apolipoprotein B/apolipoprotein A1ratio(ApoB/ApoA1)of infertile patients with polycystic ovary syndrome(PCOS)after treatment by tripraline acetate.Methods:125infertile patients with PCOS were selected and divided into experimental group(n=63)and control group(n=62)by random number table method from January 2019to January 2020.The patients in the control group were treated with clomiphene citrate and the patients in the experimental group were treated with tripraline acetate.The clinical efficacy,the levels of serum SHBG,AGEs,testosterone(T),estradiol(E_(2)),luteinizing hormone(LH),and follicle stimulating hormone(FSH),the ApoB/ApoA1value,the endometrial thickness on ovulation day,the number of mature follicles,the cycle ovulation rate,and the incidence of adverse reactions of the patients were compared between the two groups.Results:After treatment,the total effective rate(90.5%)of the patients in the experimental group was significantly higher than that(71.0%)of the patients in the control group(P<0.05).The serum SHBG of the patients in the two groups had increased significantly,and the ApoB/ApoA1value and the AGEs level of the patients in the two groups had decreased significantly,and the change degrees of which of the patients in the experimental group were significantly higher than those of the patients in the control group.The levels of serum T,E_(2),LH,and FSH of the patients in the two groups had decreased significantly,and which of the patients in the experimental group were significantly lower than those of the patients in the control group.The endometrial thickness on the ovulation day and the number of mature follicles of the patients in the experimental group were significantly higher than those of the patients in the control group(all P<0.05).There were no significant differences in the incidence of adverse reactions(12.7%vs.8.1%)and the treatment cost of the patients between the two groups(P>0.05).Conclusion:Tripraline acetate for treating the infertility patients with PCOS can effectively improve the levels of their serum SHBG and AGEs,and the ratio of ApoB/ApoA1,which has better effectiveness with good safety.