针灸八髎穴联合脱氢表雄酮对卵巢功能不全合并不孕症患者的治疗效果

Therapeutic effect of acupuncture and moxibustion at Bliao point combined with dehydroepiandrosterone for treating infertility women with premature ovarian insufficiency

目的:探讨针灸八髎穴联合脱氢表雄酮(DHEA)对早发性卵巢功能不全(POI)合并不孕症患者的治疗效果。方法:选取本院2018年1月-2020年12月收治的POI合并不孕症患者108例,随机分为观察组和对照组,每组54例,对照组给予黄体支持+DHEA治疗,观察组黄体支持+DHEA+针灸八髎穴治疗;观察比较治疗前后卵巢储备功能、子宫动脉血流、子宫内膜及治疗后6个月妊娠情况。结果:观察组临床疗效总有效率高于对照组(88.9%比66.7%,P<0.05)。治疗后两组抗苗勒管激素(AMH)、卵巢总体积(TOV)、窦卵泡数(AFC)较治疗前明显升高,且观察组大于对照组(P<0.05);两组PI、RI、S/D明显降低,且观察组低于对照组(P<0.05);两组子宫内膜厚度明显增加,且观察组高于对照组;观察组A型子宫内膜、妊娠率(18.5%比5.6%)高于对照组(P<0.05)。结论:针灸八髎穴联合脱氢表雄酮治疗POI合并不孕症患者能进一步增强患者卵巢储备功能,改善子宫动脉血流,促进子宫内膜生长,从而提高患者自然妊娠率。

Objective:To investigate the therapeutic effect of acupuncture and moxibustion at Bliao point combined with dehydroepiandrosterone(DHEA)for treating infertility women with premature ovarian insufficiency(POI).Methods:A total of 108infertility women with POI 2020were selected and randomly divided into two groups(54cases in each group)from January 2018to December.The women in the control group were given treatment of luteal support combined with DHEA,and the women in the observation group were given treatment of luteal support and DHEA combined with acupuncture and moxibustion at Bliao point.The values of ovarian reserve function,uterine artery blood flow,endometrial thickness before and after treatment,and the pregnant situation of the women in 6months after treatment were observed and compared between the two groups.Results:The total effective rate of the women in the observation group was significantly higher than that of the women in the control group(P<0.05).The anti-Mullerian hormone(AMH)level and the total ovarian volume(TOV)value,and the number of antral follicle count(AFC)of the women after treatment in the two groups had increased significantly,and which of the women in the observation group were significantly higher than those of the women in the control group(P<0.05).The values of PI,RI and S/D of the women after treatment in the two groups had decreased significantly,and which of the women in the observation group were significantly lower than those of the women in the control group(P<0.05).The endometrial thickness of the women after treatment in the two groups had increased significantly,and which of the women in the observation group was significantly higher than that of the women in the control group.The type A of endometrium and the pregnancy rate of the women in the observation group were significantly higher than those of the women in the control group(P<0.05).Conclusion:Acupuncture and moxibustion at Bliao point combined with DHEA for treating the infertility women with POI can further enhance their ovarian reserve function,improve their blood flow of the uterine artery,and promote the growth of their endometrium,thereby increasing the natural pregnancy rate of these women.