补肾舒肝法联合低分子肝素钠治疗血栓前状态引起的复发性流产效果

Efficacy of kidney-tonifying and liver-relieving method combined with low molecular weight heparin for treating women with recurrent miscarriage caused by prethrombotic state

目的:探讨补肾舒肝法联合低分子肝素钠治疗血栓前状态引起的复发性流产疗效。方法:回顾性收集2018年1月-2020年10月在本院诊疗的由血栓前状态引起的复发性流产患者100例临床资料,根据治疗方法分为西医组和中西医组各50例,均给予常规低分子肝素钠治疗,中西医组加用补肾舒肝法治疗。观察两组治疗前后血栓前状态、临床疗效及不良结局。结果:治疗后纤溶酶原激活抑制剂-1、D-二聚体、组织型纤溶酶原激活物、蛋白C活性、抗凝血酶Ⅲ活性、蛋白S活性中西医组均优于西医组,治疗有效率中西医组(90.0%)高于西医组(72.0%),流产、早产胎儿存活、阴道出血、新生儿畸形、死胎等不良结局发生率中西医组(4.0%)低于西医组(16.0%)(P<0.05)。结论:补肾舒肝法联合低分子肝素钠治疗血栓前状态引起的复发性流产,可改善患者血栓前状态,提高临床效果,降低不良妊娠结局。

Objective:To investigate the efficacy of kidney-tonifying and liver-relieving method combined with low molecular weight heparin for treating women with recurrent miscarriage caused by prethrombotic state.Methods:The clinical data of 100women with recurrent miscarriage caused by prethrombotic state from January 2018to October 2020were collected retrospectively.These women were divided into study group and control group(50cases in each group)according to the random number table method.The women in the control group were treated with conventional low-molecular-weight heparin sodium,and the women in the study group were treated with conventional low-molecular?weight heparin sodium combined with kidney-tonifying and liver-relieving method.The prethrombotic status,the clinical efficacy,and the adverse outcomes of the women before and after treatment were observed.Results:The levels of plasminogen activator inhibitor-1,D-dimer,tissue plasminogen activator,protein C activity,antithrombinⅢactivity,and protein S activity of the women in the study group after treatment were significantly better than those of the women in the control group.The therapic effective rate(90.0%)of the women in the study group was significantly higher than that(72.0%)of the women in the control group.The incidence of adverse pregnancy outcomes(4.0%),such as abortion,premature fetal survival,vaginal bleeding,neonatal malformation,and stillbirth of the women in the study group was significantly lower than that(16.0%)of the women in the control group(P<0.05).Conclusion:Kidney-tonifying and liver-relieving method combined with low molecular weight heparin for treating the women with recurrent miscarriage has better effectiveness,which can reduce their recurrence rate of miscarriage,increase their live birth rate and improve their prethrombotic state.It has certain reference value in the clinical treatment of recurrent miscarriage.