复方丹参注射液联合拉贝洛尔治疗子痫前期对患者外周血氧化应激反应及分娩结局的影响

Influence of compound danshen injection combined with labetalol for treating pregnant women with preeclampsia on their oxidative stress reaction factors level in peripheral blood and delivery outcomes

目的:探讨复方丹参注射液联合拉贝洛尔治疗子痫前期对患者外周血氧化应激反应及分娩结局的影响。方法:选取本院2019年6月-2020年12月治疗的100例子痫前期患者,随机数字表法分为两组各50例,对照组应用硫酸镁注射液、盐酸拉贝洛尔治疗,观察组在对照组基础上加用复方丹参注射液。对比两组治疗前后症状改善、外周血氧化应激反应因子变化以及不良妊娠结局。结果:相比治疗前,治疗后两组舒张压、收缩压、24h尿蛋白水平,以及血清血管紧张素Ⅱ(AngⅡ)、脂质过氧化物(LPO)、丙二醛(MDA)、蛋白质氧化产物(AOPP)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均降低且观察组低于对照组(均P<0.05)。观察组新生儿体重(2.77±0.33 kg)、5min Apgar评分(8.03±1.44分)均高于对照组(2.14±0.40 kg、6.78±0.35分)(均P<0.05),治疗期间不良反应总发生率观察组(12.0%)与对照组(8.0%)无差异(P>0.05)。不良妊娠结局总发生率观察组(18.0%)低于对照组(38.0%)(P<0.05)。结论:联合应用复方丹参注射液和拉贝洛尔治疗子痫前期,能够有效减轻临床症状,减轻外周血氧化应激及炎症反应,有利于维持胎儿的生长发育,减少不良妊娠结局的发生。

Objective:To investigate the influence of compound danshen injection combined with labetalol for treating pregnant women with preeclampsia on their oxidative stress reaction factors level in peripheral blood and their delivery outcomes.Methods:100 pregnant women with preeclampsia were selected and were divided into two groups(50 cases in each group)from June 2019 to December 2020.The women in the control group were treated with magnesium sulfate injection and labetalol hydrochloride,while the women in the observation group were treated with compound danshen injection combined with magnesium sulfate injection and labetalol hydrochloride.The improvement of symptoms,the change of oxidative stress response factors levels in peripheral blood,or the incidence of adverse pregnancy outcomes of the women before and after treatment was compared between the two groups.Results:The values of diastolic blood pressure,systolic blood pressure,24 h urinary protein,and the levels of serum angiotensinⅡ(AngⅡ),lipid peroxide(LPO),malondialdehyde(MDA),protein oxidation product(AOPP),C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)of the women in the two groups after treatment had decreased significantly,and which of the women in the observation group were significantly lower than those of the women in the control group(all P<0.05).The values of neonatal weight(2.77±0.33 kg)and Apgar score(8.03±1.44 points)in the observation group were significantly higher than those(2.14±0.40 kg and 6.78±0.35 points)in the control group(all P<0.05).There was no significant difference in the total incidence of adverse reactions(12.0%vs.8.0%)of the women between the two groups(P>0.05).The total incidence of adverse pregnancy outcomes(18.0%)of the women in the observation group was significantly lower than that(38.0%)of the women in the control group(P<0.05).Conclusion:Compound danshen injection combined with labetalol for treating pregnant women can effectively alleviate their clinical symptoms,reduce the oxidative stress and inflammatory reaction factors levels in peripheral blood,which can help to maintain the growth and development of fetus and reduce the occurrence of adverse pregnancy outcomes.