妊娠早期先兆流产患者血中纤维蛋白原、D-二聚体、血小板水平及临床意义

The levels of fibrinogen,D-dimer,and platelet in venous blood of pregnant women with threatened abortion during early pregnancy and their clinical significance

目的:初步探讨妊娠早期先兆流产患者血中纤维蛋白原(Fg)、D-二聚体(D-D)和血小板(PLT)水平及其临床意义。方法:选取2018年1月-2020年1月本院收治的先兆流产患者60例为先兆流产组,产前检查正常妊娠女性59例作为对照组,检测静脉血Fg、D-D和PLT水平,比较两组以及先兆流产组不同流产史、分娩结局水平差异。结果:先兆流产组D-D(0.64±0.31mg/L)、Fg(4.01±0.85g/L)和PLT[(236.15±46.23×10^(9)/L]水平均高于对照组[0.42±0.28mg/L、3.41±0.65g/L、(215.27±48.29)×10^(9)/L](P<0.05);先兆流产组妊娠结局为顺利分娩、难免流产和过期流产者间D-D水平有差异(P<0.05),流产<2次者D-D、Fg和PLT水平均低于≥2次者(均P<0.05)。结论:妊娠早期先兆流产患者血中D-D、Fg和PLT水平异常升高且随流产史增加而升高,提示临床可能用于妊娠早期先兆流产和不良结局的判断。

Objective:To explore the levels of fibrinogen(Fg),D-dimer(D-D),and platelet(PLT)in venous blood of pregnant women with threatened abortion during early pregnancy,and to study their clinical significance.Methods:60 pregnant women with threatened abortion were selected in study group and 59 normal pregnant women were selected in control group from January 2018 to January 2020.Venous blood samples of these women were collected to detect their Fg,DD,and PLT levels.The levels of Fg,DD,and PLT of the women were compared between the two groups,and which were also compared among the women with different abortion history and among the women with different pregnancy outcomes in the study group.Results:The levels of DD,Fg,and PLT of the women in the study group were significantly higher than those of the women in the control group(P<0.05).There were significantly different in D-D level of the women in the study group among the women with natural delivery,the women with inevitable abortion,and the women with missed abortion(P<0.05).The levels of DD,Fg,and PLT of the women with abortions less than twice were significantly lower than the women with twice or more abortions(P<0.05).Conclusion:The D-D,Fg,and PLT levels in venous blood of the pregnant women with threatened abortion during the first trimester of pregnancy are abnormal increasing,and which increase with the increase of the abortion times,so it suggests that the D-D,Fg,and PLT levels may be used to judge threatened abortion during early pregnancy and the adverse outcomes of the pregnant women.